ENSMUSG00000032244


Mus musculus

Features
Gene ID: ENSMUSG00000032244
  
Biological name :Fem1b
  
Synonyms : B / Fem1b / Q9Z2G0
  
Possible biological names infered from orthology : fem-1 homolog B / Q9UK73
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: B
Gene start: 62791821
Gene end: 62811934
  
Corresponding Affymetrix probe sets: 10594315 (MoGene1.0st)   1418323_at (Mouse Genome 430 2.0 Array)   1418324_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034775
NCBI entrez gene - 14155     See in Manteia.
MGI - MGI:1335087
RefSeq - NM_010193
RefSeq Peptide - NP_034323
swissprot - Q9Z2G0
Ensembl - ENSMUSG00000032244
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fem1bENSDARG00000062636Danio rerio
 FEM1BENSGALG00000028906Gallus gallus
 FEM1BENSG00000169018Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
C / Fem1c / Q8CEF1 / Q96JP0* / fem-1 homolog C*ENSMUSG0000003331941
A-B / Q8C0T1 / 4931440F15Rik / FEM1A* / Q9BSK4* / fem-1 homolog A*ENSMUSG0000007815739
A-A / Fem1a / Q9Z2G1 / Q9BSK4* / fem-1 homolog A*ENSMUSG0000004368339


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002070 epithelial cell maturation IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0016567 protein ubiquitination IDA
 biological_processGO:0051438 regulation of ubiquitin-protein transferase activity IEA
 biological_processGO:0060442 branching involved in prostate gland morphogenesis IMP
 biological_processGO:0060743 epithelial cell maturation involved in prostate gland development IMP
 biological_processGO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:2000001 regulation of DNA damage checkpoint IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005123 death receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000666 reduced number of prostate ducts "fewer than normal minute canals that pass the prostatic secretions to the urethra" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1tm1Mms
Genetic Background: involves: 129S1/Sv

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: NsdhlStr-1Or/NsdhlStr-1Or
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: NsdhlStr-1Or/NsdhlStr-1Or
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: NsdhlStr-1Or/NsdhlStr-1Or
Genetic Background: involves: 101/Rl * C3H/Rl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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