ENSMUSG00000043683


Mus musculus

Features
Gene ID: ENSMUSG00000043683
  
Biological name :Fem1a
  
Synonyms : A-A / Fem1a / Q9Z2G1
  
Possible biological names infered from orthology : fem-1 homolog A / Q9BSK4
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: D
Gene start: 56256793
Gene end: 56263608
  
Corresponding Affymetrix probe sets: 10446071 (MoGene1.0st)   1423583_at (Mouse Genome 430 2.0 Array)   1437063_at (Mouse Genome 430 2.0 Array)   1453560_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057996
NCBI entrez gene - 14154     See in Manteia.
MGI - MGI:1335089
RefSeq - NM_010192
RefSeq Peptide - NP_034322
swissprot - Q9Z2G1
Ensembl - ENSMUSG00000043683
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FEM1AENSGALG00000004168Gallus gallus
 FEM1AENSG00000141965Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A-B / Q8C0T1 / 4931440F15Rik / FEM1A* / Q9BSK4* / fem-1 homolog A*ENSMUSG0000007815797
C / Fem1c / Q8CEF1 / Q96JP0* / fem-1 homolog C*ENSMUSG0000003331964
B / Fem1b / Q9Z2G0 / Q9UK73* / fem-1 homolog B*ENSMUSG0000003224438


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IDA
 biological_processGO:0050728 negative regulation of inflammatory response ISO
 biological_processGO:0051438 regulation of ubiquitin-protein transferase activity ISS
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0031867 EP4 subtype prostaglandin E2 receptor binding ISO


Pathways (from Reactome)
Pathway description
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Col2a1Rgsc413/Col2a1Rgsc413
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col2a1Rgsc413/Col2a1Rgsc413
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Col2a1Rgsc413/Col2a1Rgsc413
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0003269 colonic polyps "abnormal tissue masses that protrude into the lumen of the colon and are tethered to the wall of the colon" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Col2a1Rgsc413/Col2a1Rgsc413
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col2a1Rgsc413/Col2a1Rgsc413
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0012436 increased colon tumor incidence "greater than the expected number of neoplasms in the colon, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith]
Show

Allelic Composition: Col2a1Rgsc413/Col2a1Rgsc413
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0013298 increased susceptibility to colitis induced morbidity/mortality " increased likelihood that an organism will display the expected moribund state caused by colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:Annie_Speak]
Show

Allelic Composition: Col2a1Rgsc413/Col2a1Rgsc413
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0013956 decreased colon length "reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]
Show

Allelic Composition: Col2a1Rgsc413/Col2a1Rgsc413
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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