ENSMUSG00000032295


Mus musculus

Features
Gene ID: ENSMUSG00000032295
  
Biological name :Man2c1
  
Synonyms : Alpha-mannosidase 2C1 / Man2c1 / Q91W89
  
Possible biological names infered from orthology : mannosidase alpha class 2C member 1 / Q9NTJ4
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: B
Gene start: 57130690
Gene end: 57142722
  
Corresponding Affymetrix probe sets: 10585652 (MoGene1.0st)   1423687_a_at (Mouse Genome 430 2.0 Array)   1423688_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124304
Ensembl peptide - ENSMUSP00000124124
Ensembl peptide - ENSMUSP00000124378
Ensembl peptide - ENSMUSP00000125549
Ensembl peptide - ENSMUSP00000125478
Ensembl peptide - ENSMUSP00000125277
Ensembl peptide - ENSMUSP00000125186
Ensembl peptide - ENSMUSP00000034836
Ensembl peptide - ENSMUSP00000123840
Ensembl peptide - ENSMUSP00000124005
Ensembl peptide - ENSMUSP00000124020
NCBI entrez gene - 73744     See in Manteia.
MGI - MGI:1920994
RefSeq - XM_017313626
RefSeq - XM_006511494
RefSeq - XM_006511495
RefSeq - XM_006511496
RefSeq - XM_006511499
RefSeq - XM_011242824
RefSeq - XM_017313619
RefSeq - XM_017313620
RefSeq - XM_017313621
RefSeq - XM_017313622
RefSeq - XM_017313623
RefSeq - XM_017313624
RefSeq - XM_017313625
RefSeq - NM_028636
RefSeq - XM_006511493
RefSeq Peptide - NP_082912
swissprot - E9PYM7
swissprot - E0CZB0
swissprot - E0CYW2
swissprot - F6TAQ6
swissprot - F6TFL1
swissprot - F6U7S0
swissprot - F8WIE1
swissprot - E0CXM6
swissprot - E0CXI0
swissprot - E9PZ88
swissprot - Q91W89
Ensembl - ENSMUSG00000032295
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 man2c1ENSDARG00000079835Danio rerio
 MAN2C1ENSGALG00000001615Gallus gallus
 MAN2C1ENSG00000140400Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000602  Glycoside hydrolase family 38, N-terminal domain
 IPR011013  Galactose mutarotase-like domain superfamily
 IPR011330  Glycoside hydrolase/deacetylase, beta/alpha-barrel
 IPR011682  Glycosyl hydrolase family 38, C-terminal
 IPR015341  Glycoside hydrolase family 38, central domain
 IPR027291  Glycoside hydrolase 38, N-terminal domain superfamily
 IPR028995  Glycoside hydrolase families 57/38, central domain superfamily
 IPR037094  Glycoside hydrolase family 38, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006013 mannose metabolic process IEA
 biological_processGO:0006517 protein deglycosylation IBA
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005773 vacuole IBA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004559 alpha-mannosidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Lysosomal oligosaccharide catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Smotm2Amc/Smotm2Amc,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S/Sv * 129X1/SvJ

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smotm2Amc/Smotm2Amc,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S/Sv * 129X1/SvJ

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Smotm2Amc/Smotm2Amc,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S/Sv * 129X1/SvJ

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smotm2Amc/Smotm2Amc,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S/Sv * 129X1/SvJ

Allelic Composition: Man2c1tm1.1Tbec/Man2c1+
Genetic Background: B6N.129P2-Man2c1tm1.1Tbec

 MP:0003005 abnormal hippocampal fimbria "malformations in the flattened band of efferent fibers arising from the subiculum and medial border of the hippocampus, which then thickens to form the fornix and fibers of the hippocampal commissure" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Smotm2Amc/Smotm2Amc,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S/Sv * 129X1/SvJ

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Smotm2Amc/Smotm2Amc,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S/Sv * 129X1/SvJ

 MP:0003271 abnormal duodenum morphology "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Smotm2Amc/Smotm2Amc,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S/Sv * 129X1/SvJ

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smotm2Amc/Smotm2Amc,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S/Sv * 129X1/SvJ

 MP:0005440 increased glycogen level "greater than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smotm2Amc/Smotm2Amc,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S/Sv * 129X1/SvJ

 MP:0008025 brain vacuoles "the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smotm2Amc/Smotm2Amc,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S/Sv * 129X1/SvJ

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smotm2Amc/Smotm2Amc,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S/Sv * 129X1/SvJ

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smotm2Amc/Smotm2Amc,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S/Sv * 129X1/SvJ

 MP:0008128 abnormal brain internal capsule morphology "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smotm2Amc/Smotm2Amc,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S/Sv * 129X1/SvJ

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
Show

Allelic Composition: Smotm2Amc/Smotm2Amc,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S/Sv * 129X1/SvJ

 MP:0008882 abnormal enterocyte physiology "any functional anomaly of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen" [CL:0000584, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smotm2Amc/Smotm2Amc,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S/Sv * 129X1/SvJ

Allelic Composition: Man2c1tm1.1Tbec/Man2c1+
Genetic Background: B6N.129P2-Man2c1tm1.1Tbec

 MP:0008917 abnormal oligodendrocyte physiology "any functional anomaly of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MESH:A08.637.600]
Show

Allelic Composition: Smotm2Amc/Smotm2Amc,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S/Sv * 129X1/SvJ

 MP:0010400 increased liver glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smotm2Amc/Smotm2Amc,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S/Sv * 129X1/SvJ

 MP:0010762 abnormal microglial cell activation "any anomaly in change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smotm2Amc/Smotm2Amc,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S/Sv * 129X1/SvJ

 MP:0011377 renal glomerulus fibrosis "formation of fibrous tissue in the renal glomerulus as a result of repair or a reactive process" [MGI:anna]
Show

Allelic Composition: Smotm2Amc/Smotm2Amc,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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