| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0001364 | decreased anxiety-related response | "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0001399 | hyperactivity | "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0001405 | impaired coordination | "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0001489 | decreased startle reflex | "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0001516 | abnormal motor coordination/ balance | "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0001636 | irregular heartbeat | "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0002833 | increased heart weight | "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0003233 | prolonged QT interval | "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0003461 | abnormal response to novel object | "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0004089 | dilated sarcoplasmic reticulum | "an expansion in the volume in the endoplasmic reticulum of skeletal and cardiac muscle, i.e. the complex of vesicles, tubules, and cisternae that form a continuous structure around striated myofibrils, with a repetition of structure within each sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0004566 | myocardial fiber degeneration | "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0004937 | dilated heart | "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0005330 | cardiomyopathy | "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0005333 | decreased heart rate | "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0006036 | abnormal mitochondrial physiology | |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0008873 | increased sensitivity to xenobiotics | "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0009732 | ventricular premature beat | "a heartbeat is initiated by abnormal electrical activation originating in the heart ventricles rather than by the sinoatrial node, the normal heartbeat initiator, before a normal heartbeat would occur" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0009766 | increased sensitivity to xenobiotic induced morbidity/mortality | "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0009777 | abnormal behavioral response to anesthetic | "anomaly in the behavioral changes that follow exposure to an anesthetizing agent" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0010052 | increased grip strength | "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0010392 | prolonged QRS complex duration | "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0010394 | decreased QRS amplitude | "reduction in the size (height or maximum displacement) of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction, suggesting ventricular excitation defects" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0010519 | atrioventricular block | "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0010520 | sinoatrial block | "a partial or complete obstruction of the impulse leaving the sinoatrial node preventing it from activating atrial muscle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0010632 | cardiac muscle necrosis | "pathological death of cardiomyocytes or a portion of the cardiac muscle tissue; usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0011634 | abnormal mitochondrial inner membrane morphology | "any structural anomaly of the inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope, which is highly folded to form cristae" [GO:0005743] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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| MP:0011639 | decreased mitochondrial DNA content | "less than expected amount of DNA contained within the mirochondria of a eukaryotic cell" [MGI:csmith] |
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw
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