ENSMUSG00000032400


Mus musculus

Features
Gene ID: ENSMUSG00000032400
  
Biological name :Zwilch
  
Synonyms : Zwilch / zwilch kinetochore protein
  
Possible biological names infered from orthology : Q9H900
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: C
Gene start: 64137144
Gene end: 64173104
  
Corresponding Affymetrix probe sets: 10594426 (MoGene1.0st)   1416757_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135585
Ensembl peptide - ENSMUSP00000135705
Ensembl peptide - ENSMUSP00000112790
Ensembl peptide - ENSMUSP00000115556
Ensembl peptide - ENSMUSP00000116187
Ensembl peptide - ENSMUSP00000134782
Ensembl peptide - ENSMUSP00000134850
Ensembl peptide - ENSMUSP00000134966
Ensembl peptide - ENSMUSP00000135328
NCBI entrez gene - 68014     See in Manteia.
MGI - MGI:1915264
RefSeq - NM_026507
RefSeq Peptide - NP_080783
swissprot - H3BIZ1
swissprot - H3BJ52
swissprot - H3BJF6
swissprot - H3BKB9
swissprot - H3BKZ0
swissprot - H3BL96
swissprot - G3X9Z0
swissprot - F6TCM4
swissprot - D3Z6K4
Ensembl - ENSMUSG00000032400
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A5WWB6ENSDARG00000057100Danio rerio
 ZWILCHENSGALG00000007736Gallus gallus
 Q9H900ENSG00000174442Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR018630  RZZ complex, subunit Zwilch


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007093 mitotic cell cycle checkpoint IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:1990423 RZZ complex IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Tbx4tm4b(EUCOMM)Wtsi/Tbx4+
Genetic Background: C57BL/6N-Tbx4tm4b(EUCOMM)Wtsi/Ucd

Allelic Composition: Zwilchtm1.1(KOMP)Vlcg/Zwilchtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Zwilchtm1.1(KOMP)Vlcg/J

 MP:0001711 abnormal placenta 
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Allelic Composition: Zfp260tm1b(NCOM)Mfgc/Zfp260tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Zfp260tm1b(NCOM)Mfgc/Tcp

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Zwilchtm1.1(KOMP)Vlcg/Zwilchtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Zwilchtm1.1(KOMP)Vlcg/J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx4tm4b(EUCOMM)Wtsi/Tbx4+
Genetic Background: C57BL/6N-Tbx4tm4b(EUCOMM)Wtsi/Ucd

Allelic Composition: Zwilchtm1.1(KOMP)Vlcg/Zwilchtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Zwilchtm1.1(KOMP)Vlcg/J

 MP:0004258 abnormal placenta size "anomaly in the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zwilchtm1.1(KOMP)Vlcg/Zwilchtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Zwilchtm1.1(KOMP)Vlcg/J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Zwilchtm1.1(KOMP)Vlcg/Zwilchtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Zwilchtm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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