ENSG00000174442


Homo sapiens

Features
Gene ID: ENSG00000174442
  
Biological name :ZWILCH
  
Synonyms : Q9H900 / ZWILCH / zwilch kinetochore protein
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q22.31
Gene start: 66504959
Gene end: 66550128
  
Corresponding Affymetrix probe sets: 218349_s_at (Human Genome U133 Plus 2.0 Array)   222606_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000477955
Ensembl peptide - ENSP00000311429
Ensembl peptide - ENSP00000402217
Ensembl peptide - ENSP00000455548
Ensembl peptide - ENSP00000456689
Ensembl peptide - ENSP00000437749
Ensembl peptide - ENSP00000454737
Ensembl peptide - ENSP00000455336
NCBI entrez gene - 55055     See in Manteia.
OMIM - 609984
RefSeq - NM_001287821
RefSeq - NM_001287823
RefSeq - NM_017975
RefSeq - NM_001287822
RefSeq Peptide - NP_001274750
RefSeq Peptide - NP_001274752
RefSeq Peptide - NP_060445
RefSeq Peptide - NP_001274751
swissprot - Q9H900
swissprot - H3BPI7
swissprot - H3BQ07
swissprot - H3BSG1
Ensembl - ENSG00000174442
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A5WWB6ENSDARG00000057100Danio rerio
 ZWILCHENSGALG00000007736Gallus gallus
 ZwilchENSMUSG00000032400Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR018630  RZZ complex, subunit Zwilch


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0007093 mitotic cell cycle checkpoint IMP
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IDA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:1990423 RZZ complex IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000086827 ZW10 / O43264 / zw10 kinetochore protein  / complex
 ENSG00000184445 KNTC1 / P50748 / kinetochore associated 1  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr