ENSG00000086827


Homo sapiens

Features
Gene ID: ENSG00000086827
  
Biological name :ZW10
  
Synonyms : O43264 / ZW10 / zw10 kinetochore protein
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q23.2
Gene start: 113733187
Gene end: 113773811
  
Corresponding Affymetrix probe sets: 204812_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000200135
Ensembl peptide - ENSP00000439197
Ensembl peptide - ENSP00000440879
NCBI entrez gene - 9183     See in Manteia.
OMIM - 603954
RefSeq - XM_017018559
RefSeq - NM_004724
RefSeq - XM_017018558
RefSeq Peptide - NP_004715
swissprot - O43264
swissprot - F5H3C1
Ensembl - ENSG00000086827
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zw10ENSDARG00000018738Danio rerio
 ZW10ENSGALG00000040155Gallus gallus
 Zw10ENSMUSG00000032264Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009361  RZZ complex, subunit Zw10


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000070 mitotic sister chromatid segregation IDA
 biological_processGO:0000132 establishment of mitotic spindle orientation IMP
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport IMP
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS
 biological_processGO:0007030 Golgi organization IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0007080 mitotic metaphase plate congression IMP
 biological_processGO:0007093 mitotic cell cycle checkpoint IDA
 biological_processGO:0007094 mitotic spindle assembly checkpoint IBA
 biological_processGO:0007096 regulation of exit from mitosis IDA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0034501 protein localization to kinetochore IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051321 meiotic cell cycle TAS
 biological_processGO:0065003 protein-containing complex assembly IDA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000922 spindle pole IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005828 kinetochore microtubule IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0070939 Dsl1/NZR complex IDA
 cellular_componentGO:1990423 RZZ complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019237 centromeric DNA binding TAS


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
COPI-dependent Golgi-to-ER retrograde traffic
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000168818 STX18 / Q9P2W9 / syntaxin 18  / reaction
 ENSG00000135249 RINT1 / Q6NUQ1 / RAD50 interactor 1  / complex
 ENSG00000053501 USE1 / Q9NZ43 / unconventional SNARE in the ER 1  / reaction
 ENSG00000174442 Q9H900 / ZWILCH / zwilch kinetochore protein  / complex
 ENSG00000113734 BNIP1 / Q12981 / BCL2 interacting protein 1  / reaction
 ENSG00000151779 NBAS / A2RRP1 / neuroblastoma amplified sequence  / complex
 ENSG00000184445 KNTC1 / P50748 / kinetochore associated 1  / complex






 

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