ENSG00000184445


Homo sapiens

Features
Gene ID: ENSG00000184445
  
Biological name :KNTC1
  
Synonyms : kinetochore associated 1 / KNTC1 / P50748
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.31
Gene start: 122527246
Gene end: 122626396
  
Corresponding Affymetrix probe sets: 206316_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000437344
Ensembl peptide - ENSP00000408760
Ensembl peptide - ENSP00000439119
Ensembl peptide - ENSP00000328236
Ensembl peptide - ENSP00000397140
Ensembl peptide - ENSP00000397992
NCBI entrez gene - 9735     See in Manteia.
OMIM - 607363
RefSeq - XM_017020257
RefSeq - XM_011539027
RefSeq - XM_011539029
RefSeq - XM_011539030
RefSeq - XM_017020254
RefSeq - XM_017020255
RefSeq - XM_017020256
RefSeq - NM_014708
RefSeq - XM_006719706
RefSeq Peptide - NP_055523
swissprot - F5H5V0
swissprot - H0YFL5
swissprot - J3KQF2
swissprot - E7ES84
swissprot - P50748
Ensembl - ENSG00000184445
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kntc1ENSDARG00000101670Danio rerio
 KNTC1ENSGALG00000004515Gallus gallus
 Kntc1ENSMUSG00000029414Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR019527  RZZ complex, subunit KNTC1/ROD, C-terminal
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0007093 mitotic cell cycle checkpoint IDA
 biological_processGO:0007096 regulation of exit from mitosis NAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0065003 protein-containing complex assembly NAS
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000922 spindle pole IDA
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005828 kinetochore microtubule IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:1990423 RZZ complex IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000174442 Q9H900 / ZWILCH / zwilch kinetochore protein  / complex
 ENSG00000086827 ZW10 / O43264 / zw10 kinetochore protein  / complex






 

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contact: otassy@igbmc.fr