ENSMUSG00000032633


Mus musculus

Features
Gene ID: ENSMUSG00000032633
  
Biological name :Flcn
  
Synonyms : Flcn / Folliculin / Q8QZS3
  
Possible biological names infered from orthology : AC055811.2 / Q8NFG4
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.3
Gene start: 59791408
Gene end: 59810016
  
Corresponding Affymetrix probe sets: 10386427 (MoGene1.0st)   1423663_at (Mouse Genome 430 2.0 Array)   1438167_x_at (Mouse Genome 430 2.0 Array)   1456744_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037675
Ensembl peptide - ENSMUSP00000091696
Ensembl peptide - ENSMUSP00000099758
NCBI entrez gene - 216805     See in Manteia.
MGI - MGI:2442184
RefSeq - NM_146018
RefSeq - NM_001271356
RefSeq - NM_001271357
RefSeq - XM_011248905
RefSeq Peptide - NP_001258286
RefSeq Peptide - NP_666130
RefSeq Peptide - NP_001258285
swissprot - Q8QZS3
swissprot - Z4YJH7
Ensembl - ENSMUSG00000032633
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 flcnENSDARG00000062385Danio rerio
 ENSGALG00000004816Gallus gallus
 AC055811.2ENSG00000264187Homo sapiens
 FLCNENSG00000154803Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR021713  Folliculin
 IPR032035  Folliculin, C-terminal
 IPR037520  Folliculin, N-terminal
 IPR037521  Folliculin/SMCR8, tripartite DENN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001932 regulation of protein phosphorylation ISS
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0007043 cell-cell junction assembly IMP
 biological_processGO:0010508 positive regulation of autophagy ISO
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010823 negative regulation of mitochondrion organization IMP
 biological_processGO:0016525 negative regulation of angiogenesis NAS
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030308 negative regulation of cell growth ISS
 biological_processGO:0030336 negative regulation of cell migration ISS
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway ISO
 biological_processGO:0031929 TOR signaling ISO
 biological_processGO:0032006 regulation of TOR signaling IMP
 biological_processGO:0032007 negative regulation of TOR signaling IMP
 biological_processGO:0032008 positive regulation of TOR signaling IMP
 biological_processGO:0032465 regulation of cytokinesis ISS
 biological_processGO:0035024 negative regulation of Rho protein signal transduction ISS
 biological_processGO:0035065 regulation of histone acetylation IMP
 biological_processGO:0045785 positive regulation of cell adhesion ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0051898 negative regulation of protein kinase B signaling IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:1900181 negative regulation of protein localization to nucleus ISS
 biological_processGO:1901723 negative regulation of cell proliferation involved in kidney development IMP
 biological_processGO:1901856 negative regulation of cellular respiration IMP
 biological_processGO:1901859 negative regulation of mitochondrial DNA metabolic process IMP
 biological_processGO:1901862 negative regulation of muscle tissue development IMP
 biological_processGO:1901874 negative regulation of post-translational protein modification IMP
 biological_processGO:2000973 regulation of pro-B cell differentiation IMP
 biological_processGO:2001170 negative regulation of ATP biosynthetic process IMP
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0044291 cell-cell contact zone ISS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0044877 protein-containing complex binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000530 abnormal kidney vasculature "malformation or malfunctioning of the blood vessel network of the organ of excretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Agrptm2(DTR)Rpa/Agrptm2(DTR)Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000533 kidney hemorrhage "bleeding in the organ of excretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx2tm1Gss/Runx2+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agrptm2(DTR)Rpa/Agrptm2(DTR)Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: FlcnGt(RRX115)Byg/Flcn+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
Show

Allelic Composition: Fnip1tm1.2Baba/Fnip1tm1.2Baba
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agrptm2(DTR)Rpa/Agrptm2(DTR)Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Agrptm2(DTR)Rpa/Agrptm2(DTR)Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Agrptm2(DTR)Rpa/Agrptm2(DTR)Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
Show

Allelic Composition: Agrptm2(DTR)Rpa/Agrptm2(DTR)Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Flcntm1Baba/Flcntm1Baba,Fnip1tm1.1Baba/Fnip1tm1.1Baba,Fnip2tm1.1Lss/Fnip2tm1.1Lss,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * ICR

 MP:0003085 abnormal egg cylinder morphology "anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: FlcnGt(RRX115)Byg/Flcn+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Agrptm2(DTR)Rpa/Agrptm2(DTR)Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Flcntm1Btt/Flcntm1Btt,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * ICR

Allelic Composition: Flcntm1Baba/Flcntm1.1Lss,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Agrptm2(DTR)Rpa/Agrptm2(DTR)Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: FlcnGt(RRX115)Byg/Flcn+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Flcntm1Baba/Flcntm1.1Lss,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Agrptm2(DTR)Rpa/Agrptm2(DTR)Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Flcntm1Btt/Flcntm1Btt,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * ICR

 MP:0004192 abnormal kidney pyramid morphology "any structural anomaly of the conical mass of tissue, containing part of the secreting and collecting tubules, whose base faces the renal cortex" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agrptm2(DTR)Rpa/Agrptm2(DTR)Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: FlcnGt(RRX115)Byg/Flcn+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004754 abnormal kidney collecting duct "any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agrptm2(DTR)Rpa/Agrptm2(DTR)Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004860 dilated kidney collecting duct "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agrptm2(DTR)Rpa/Agrptm2(DTR)Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Flcntm1Btt/Flcntm1Btt,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * ICR

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fnip1tm1.2Baba/Fnip1tm1.2Baba
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N * SJL

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Agrptm2(DTR)Rpa/Agrptm2(DTR)Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Flcntm1Btt/Flcntm1Btt,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * ICR

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Flcntm1Btt/Flcntm1Btt,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * ICR

Allelic Composition: Flcntm1Baba/Flcntm1Baba,Fnip1tm1.1Baba/Fnip1tm1.1Baba,Fnip2tm1.1Lss/Fnip2tm1.1Lss,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * ICR

 MP:0009050 dilated proximal convoluted tubules "stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Flcntm1Btt/Flcntm1Btt,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * ICR

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Flcntm1Btt/Flcntm1Btt,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * ICR

 MP:0010294 increased kidney tumor incidence "greater than the expected number of tumors originating in the kidney in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: FlcnGt(RRX115)Byg/Flcn+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010384 increased renal carcinoma incidence "greater than the expected number of malignant neoplasms arising from kidney epithelial tissue, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Flcntm1Btt/Flcntm1Btt,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * ICR

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Agrptm2(DTR)Rpa/Agrptm2(DTR)Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Flcntm1Btt/Flcntm1Btt,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * ICR

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Agrptm2(DTR)Rpa/Agrptm2(DTR)Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: FlcnGt(RRX115)Byg/FlcnGt(RRX115)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Flcntm1Btt/Flcntm1Btt,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * ICR

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: FlcnGt(RRX115)Byg/FlcnGt(RRX115)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011363 renal glomerulus atrophy "acquired diminution of the size of the capillary loops of the kidney associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
Show

Allelic Composition: Flcntm1Btt/Flcntm1Btt,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * ICR

 MP:0011376 abnormal kidney corticomedullary boundary morphology "any structural anomaly of the region demarcating the renal medulla from the surrounding cortex; end-stage renal failure may be associated with loss of the normal corticomedullary boundary" [MGI:anna]
Show

Allelic Composition: Agrptm2(DTR)Rpa/Agrptm2(DTR)Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0011440 increased kidney cell proliferation "increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]
Show

Allelic Composition: Agrptm2(DTR)Rpa/Agrptm2(DTR)Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: FlcnGt(RRX115)Byg/Flcn+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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