ENSMUSG00000032827


Mus musculus

Features
Gene ID: ENSMUSG00000032827
  
Biological name :Ppp1r9a
  
Synonyms : Ppp1r9a / protein phosphatase 1, regulatory (inhibitor) subunit 9A
  
Possible biological names infered from orthology : protein phosphatase 1 regulatory subunit 9A / Q9ULJ8
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: A1
Gene start: 4902917
Gene end: 5165661
  
Corresponding Affymetrix probe sets: 10536297 (MoGene1.0st)   1432037_at (Mouse Genome 430 2.0 Array)   1440285_at (Mouse Genome 430 2.0 Array)   1456072_at (Mouse Genome 430 2.0 Array)   1457603_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135634
Ensembl peptide - ENSMUSP00000046906
Ensembl peptide - ENSMUSP00000126643
Ensembl peptide - ENSMUSP00000134909
Ensembl peptide - ENSMUSP00000134937
Ensembl peptide - ENSMUSP00000134943
Ensembl peptide - ENSMUSP00000135360
Ensembl peptide - ENSMUSP00000135485
Ensembl peptide - ENSMUSP00000135629
NCBI entrez gene - 243725     See in Manteia.
MGI - MGI:2442401
RefSeq - XM_017321591
RefSeq - XM_006505072
RefSeq - XM_006505073
RefSeq - XM_006505075
RefSeq - XM_006505076
RefSeq - XM_006505078
RefSeq - XM_006505079
RefSeq - XM_006505080
RefSeq - XM_006505082
RefSeq - XM_011241059
RefSeq - XM_017321590
RefSeq - NM_181595
RefSeq - XM_006505070
RefSeq - XM_006505071
RefSeq Peptide - NP_853626
swissprot - H3BKE7
swissprot - H3BKQ7
swissprot - H3BL28
swissprot - H3BJD0
swissprot - H3BJA6
swissprot - Q3UXW4
swissprot - Q7TN74
swissprot - H3BJD6
swissprot - Q8BMP0
Ensembl - ENSMUSG00000032827
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp1r9aENSDARG00000061304Danio rerio
 ENSGALG00000009686Gallus gallus
 ENSGALG00000045286Gallus gallus
 Q9ULJ8ENSG00000158528Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6R891 / Ppp1r9b / protein phosphatase 1, regulatory subunit 9BENSMUSG0000003897635
Afdn / Q9QZQ1 / Afadin / P55196* / afadin, adherens junction formation factor*ENSMUSG0000006803620
Q8K070 / Samd14 / Sterile alpha motif domain-containing protein 14 / Q8IZD0* / sterile alpha motif domain containing 14*ENSMUSG0000004718111


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR001660  Sterile alpha motif domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR029994  Neurabin-1
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IPI
 biological_processGO:0007568 aging IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0019722 calcium-mediated signaling IMP
 biological_processGO:0030833 regulation of actin filament polymerization IEA
 biological_processGO:0031175 neuron projection development ISO
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0051489 regulation of filopodium assembly IEA
 biological_processGO:0051497 negative regulation of stress fiber assembly IEA
 biological_processGO:0051823 regulation of synapse structural plasticity IEA
 biological_processGO:0051963 regulation of synapse assembly IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060999 positive regulation of dendritic spine development IEA
 biological_processGO:0061001 regulation of dendritic spine morphogenesis IEA
 biological_processGO:0097237 cellular response to toxic substance IEA
 biological_processGO:1900272 negative regulation of long-term synaptic potentiation IEA
 biological_processGO:1900454 positive regulation of long term synaptic depression IEA
 biological_processGO:1904049 negative regulation of spontaneous neurotransmitter secretion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton ISO
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030175 filopodium IDA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone ISO
 cellular_componentGO:0030864 cortical actin cytoskeleton IDA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0044326 dendritic spine neck IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:1990761 growth cone lamellipodium IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008157 protein phosphatase 1 binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0051015 actin filament binding IEA
 molecular_functionGO:0051020 GTPase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Scn11atm1Lex/Scn11atm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Scn11atm1Lex/Scn11atm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scn11atm1Lex/Scn11atm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Scn11atm1Lex/Scn11atm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0009754 enhanced behavioral response to cocaine "increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scn11atm1Lex/Scn11atm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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