ENSMUSG00000038976


Mus musculus

Features
Gene ID: ENSMUSG00000038976
  
Biological name :Ppp1r9b
  
Synonyms : Ppp1r9b / protein phosphatase 1, regulatory subunit 9B / Q6R891
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 94991035
Gene end: 95006899
  
Corresponding Affymetrix probe sets: 10380477 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000041732
Ensembl peptide - ENSMUSP00000103377
NCBI entrez gene - 217124     See in Manteia.
MGI - MGI:2387581
RefSeq - NM_172261
RefSeq Peptide - NP_758465
swissprot - Q6R891
Ensembl - ENSMUSG00000038976
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp1r9baENSDARG00000079366Danio rerio
 ppp1r9bbENSDARG00000071709Danio rerio
 PPP1R9BENSG00000108819Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ppp1r9a / protein phosphatase 1, regulatory (inhibitor) subunit 9A / Q9ULJ8* / protein phosphatase 1 regulatory subunit 9A*ENSMUSG0000003282747
Afdn / Q9QZQ1 / Afadin / P55196* / afadin, adherens junction formation factor*ENSMUSG0000006803620
Q8K070 / Samd14 / Sterile alpha motif domain-containing protein 14 / Q8IZD0* / sterile alpha motif domain containing 14*ENSMUSG000000471816


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR029921  Neurabin-2
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IMP
 biological_processGO:0001975 response to amphetamine IEA
 biological_processGO:0003006 developmental process involved in reproduction IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007015 actin filament organization IPI
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007612 learning IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016358 dendrite development IMP
 biological_processGO:0016477 cell migration ISS
 biological_processGO:0019722 calcium-mediated signaling IMP
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0030036 actin cytoskeleton organization TAS
 biological_processGO:0030042 actin filament depolymerization IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030308 negative regulation of cell growth ISO
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032515 negative regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0034695 response to prostaglandin E IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0046847 filopodium assembly ISS
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0050804 modulation of chemical synaptic transmission IEA
 biological_processGO:0060179 male mating behavior IEA
 biological_processGO:0061458 reproductive system development IEA
 biological_processGO:0071315 cellular response to morphine IMP
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071482 cellular response to light stimulus IEA
 biological_processGO:0097338 response to clozapine IEA
 biological_processGO:1901653 cellular response to peptide IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:1903119 protein localization to actin cytoskeleton IEA
 biological_processGO:1903829 positive regulation of cellular protein localization IEA
 biological_processGO:1904372 positive regulation of protein localization to actin cortical patch IEA
 biological_processGO:1904373 response to kainic acid IEA
 biological_processGO:1904386 response to L-phenylalanine derivative IEA
 biological_processGO:1990778 protein localization to cell periphery IEA
 biological_processGO:2000474 regulation of opioid receptor signaling pathway IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IDA
 cellular_componentGO:0032587 ruffle membrane ISS
 cellular_componentGO:0032591 dendritic spine membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044326 dendritic spine neck IEA
 cellular_componentGO:0044327 dendritic spine head IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:1990780 cytoplasmic side of dendritic spine plasma membrane IEA
 molecular_functionGO:0003779 actin binding TAS
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004864 protein phosphatase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008157 protein phosphatase 1 binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0031749 D2 dopamine receptor binding IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

 MP:0000813 abnormal hippocampal laminar structure "malformed or missing layers of the laminar structure of the hippocampus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

 MP:0002805 abnormal conditioned taste aversion behavior "a defect in the ability of an animal to learn to avoid food sources that were previously associated with aversive internal stimuli or sickness such as a drug that induces sickness " [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

 MP:0002885 abnormal AMPA-mediated synaptic currents "change in the measured amplitude or duration of response to stimulation of AMPA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

 MP:0003063 increased coping response "enhanced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0008236 decreased susceptibility to neuronal excitotoxicity "less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

 MP:0009754 enhanced behavioral response to cocaine "increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr