ENSMUSG00000032854


Mus musculus

Features
Gene ID: ENSMUSG00000032854
  
Biological name :Ugt8a
  
Synonyms : Q64676 / UDP galactosyltransferase 8A / Ugt8a
  
Possible biological names infered from orthology : Q16880 / UDP glycosyltransferase 8 / UGT8
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: G1
Gene start: 125865271
Gene end: 125938619
  
Corresponding Affymetrix probe sets: 10501963 (MoGene1.0st)   1419063_at (Mouse Genome 430 2.0 Array)   1419064_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050852
Ensembl peptide - ENSMUSP00000143605
NCBI entrez gene - 22239     See in Manteia.
MGI - MGI:109522
RefSeq - XM_006501310
RefSeq - NM_011674
RefSeq - XM_006501309
RefSeq Peptide - NP_035804
swissprot - Q64676
Ensembl - ENSMUSG00000032854
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ugt8ENSDARG00000037455Danio rerio
 UGT8ENSGALG00000012018Gallus gallus
 UGT8ENSG00000174607Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ugt2b34 / UDP glucuronosyltransferase 2 family, polypeptide B34 / P06133* / P16662* / P36537* / P54855* / Q9BY64* / UGT2B7* / O75310* / O75795* / UGT2B4* / UGT2B11* / UGT2B15* / UGT2B28* / ...ENSMUSG0000002926034
Ugt2b1 / UDP glucuronosyltransferase 2 family, polypeptide B1 / P06133* / P16662* / P36537* / P54855* / Q9BY64* / UGT2B7* / O75310* / O75795* / UGT2B4* / UGT2B10* / UGT2B11* / UGT2B28* / UG...ENSMUSG0000003583634
Ugt2a1 / Q6PDD0 / Ugt2a2 / UDP glucuronosyltransferase 2 family, polypeptide A2 / Q9Y4X1* / UDP glucuronosyltransferase family 2 member A2*ENSMUSG0000002926833
Q80X89 / Ugt2a1 / UDP glucuronosyltransferase 2 family, polypeptide A1 / Q9Y4X1* / UDP glucuronosyltransferase family 2 member A1 complex locus*ENSMUSG0000010667733
Ugt1a8 / UDP glucuronosyltransferase 1 family, polypeptide A8 / Q9HAW9* / Q9HAW8* / UGT1A7* / Q9HAW7* / UGT1A10* / UDP glucuronosyltransferase family 1 member A8* / UDP glucuronosyltransfer...ENSMUSG0000008967533
Ugt2b38 / UDP glucuronosyltransferase 2 family, polypeptide B38 / P06133* / P16662* / P36537* / P54855* / Q9BY64* / UGT2B7* / O75310* / O75795* / UGT2B4* / UGT2B11* / UGT2B15* / UGT2B28* / ...ENSMUSG0000006190633
P70691 / Ugt1a2 / UDP glucuronosyltransferase 1 family, polypeptide A2 / UGT1A5* / P22310* / P35503* / P35504* / UGT1A3* / UGT1A4* / UDP glucuronosyltransferase family 1 member A3* / UDP gl...ENSMUSG0000009017132
Ugt2b37 / UDP glucuronosyltransferase 2 family, polypeptide B37 / P06133* / P16662* / P36537* / P54855* / Q9BY64* / UGT2B7* / O75310* / O75795* / UGT2B4* / UGT2B11* / UGT2B15* / UGT2B28* / ...ENSMUSG0000005742532
Q8BWQ1 / Ugt2a3 / UDP glucuronosyltransferase 2 family, polypeptide A3 / Q6UWM9* / UDP glucuronosyltransferase family 2 member A3*ENSMUSG0000003578032
Ugt1a10 / UDP glycosyltransferase 1 family, polypeptide A10 / Q9HAW9* / UGT1A8* / Q9HAW7* / Q9HAW8* / UGT1A7* / UDP glucuronosyltransferase family 1 member A7* / UDP glucuronosyltransferase...ENSMUSG0000009016532
Q62452 / Ugt1a9 / UDP glucuronosyltransferase 1 family, polypeptide A9 / Q9HAW9* / Q9HAW8* / UGT1A7* / UGT1A8* / Q9HAW7* / UGT1A10* / UDP glucuronosyltransferase family 1 member A7* / UDP g...ENSMUSG0000009017532
Ugt2b5 / UDP glucuronosyltransferase 2 family, polypeptide B5 / P06133* / P16662* / P36537* / P54855* / Q9BY64* / UGT2B7* / O75310* / O75795* / UGT2B4* / UGT2B11* / UGT2B15* / UGT2B28* / UG...ENSMUSG0000005463032
Ugt2b36 / UDP glucuronosyltransferase 2 family, polypeptide B36 / P06133* / P16662* / P36537* / P54855* / Q9BY64* / UGT2B7* / O75310* / O75795* / UGT2B4* / UGT2B11* / UGT2B15* / UGT2B28* / ...ENSMUSG0000007070432
Ugt2b35 / UDP glucuronosyltransferase 2 family, polypeptide B35 / P06133* / P16662* / P36537* / P54855* / Q9BY64* / UGT2B7* / O75310* / O75795* / UGT2B4* / UGT2B11* / UGT2B15* / UGT2B28* / ...ENSMUSG0000003581132
Q6ZQM8 / Q64435 / Ugt1a7c / UDP glucuronosyltransferase 1 family, polypeptide A7C / UGT1A6* / P19224* / UDP glucuronosyltransferase family 1 member A6*ENSMUSG0000009012431
Q64435 / Ugt1a6a / UDP glucuronosyltransferase 1 family, polypeptide A6A / UGT1A6* / P19224* / UDP glucuronosyltransferase family 1 member A6*ENSMUSG0000005454531
Ugt1a6b / UDP glucuronosyltransferase 1 family, polypeptide A6B / P19224* / UGT1A6* / UDP glucuronosyltransferase family 1 member A6*ENSMUSG0000009014531
Gm43638 / Q9Y4X1* / UGT2A1* / UDP glucuronosyltransferase family 2 member A1 complex locus*ENSMUSG0000010718030
Ugt1a5 / UDP glucuronosyltransferase 1 family, polypeptide A5 / P35504* / P35503* / UGT1A3* / UGT1A4* / P22310* / UDP glucuronosyltransferase family 1 member A3* / UDP glucuronosyltransfera...ENSMUSG0000008994330
Q63886 / Ugt1a1 / UDP glucuronosyltransferase 1 family, polypeptide A1 / P22309* / UDP glucuronosyltransferase family 1 member A1*ENSMUSG0000008996030


Protein motifs (from Interpro)
Interpro ID Name
 IPR002213  UDP-glucuronosyl/UDP-glucosyltransferase
 IPR035595  UDP-glycosyltransferase family, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002175 protein localization to paranode region of axon IMP
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006665 sphingolipid metabolic process IEA
 biological_processGO:0006682 galactosylceramide biosynthetic process IEA
 biological_processGO:0007010 cytoskeleton organization IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009247 glycolipid biosynthetic process TAS
 biological_processGO:0030913 paranodal junction assembly IMP
 biological_processGO:0042552 myelination TAS
 biological_processGO:0048812 neuron projection morphogenesis IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IBA
 molecular_functionGO:0008120 ceramide glucosyltransferase activity TAS
 molecular_functionGO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity IEA
 molecular_functionGO:0015020 glucuronosyltransferase activity IBA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0016758 transferase activity, transferring hexosyl groups IEA
 molecular_functionGO:0047263 N-acylsphingosine galactosyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000436 abnormal head movements "anomalous motion of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Ugt8atm1Wst/Ugt8atm1Wst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Ugt8atm1Wst/Ugt8atm1Wst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000756 forelimb paralysis "loss of power of voluntary movement in muscles of the forlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ugt8atm1Wst/Ugt8atm1Wst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cntnap1tm1Bhat/Cntnap1tm1Bhat
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Aspanur7/Aspanur7,Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ugt8atm1Wst/Ugt8atm1Wst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Ugt8atm1Wst/Ugt8atm1Wst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Entpd1tm1Djp/Entpd1tm1Djp
Genetic Background: B6.129-Entpd1tm1Djp

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Ugt8atm1Wst/Ugt8atm1Wst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ugt8atm1Wst/Ugt8atm1Wst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ugt8atm1Wst/Ugt8atm1Wst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Ugt8atm1Wst/Ugt8atm1Wst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002654 spongiform encephalopathy "a neurodegenerative state characterized by the appearance of large vacuolated areas in the brain cells, resembling a sponge" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aspanur7/Aspanur7,Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005403 abnormal nerve conduction "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Ugt8atm1Wst/Ugt8atm1Wst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009808 reduced oligodendrocyte number "significantly fewer than the expected number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS are present" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aspanur7/Aspanur7,Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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