ENSMUSG00000033253


Mus musculus

Features
Gene ID: ENSMUSG00000033253
  
Biological name :Szt2
  
Synonyms : A2A9C3 / KICSTOR complex protein SZT2 / Szt2
  
Possible biological names infered from orthology : Q5T011 / SZT2, KICSTOR complex subunit
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.1
Gene start: 118362743
Gene end: 118409273
  
Corresponding Affymetrix probe sets: 10515649 (MoGene1.0st)   10515688 (MoGene1.0st)   10515690 (MoGene1.0st)   10515692 (MoGene1.0st)   10515694 (MoGene1.0st)   10515696 (MoGene1.0st)   10515698 (MoGene1.0st)   10515700 (MoGene1.0st)   10515702 (MoGene1.0st)   10515704 (MoGene1.0st)   10515706 (MoGene1.0st)   10515708 (MoGene1.0st)   10515710 (MoGene1.0st)   10515712 (MoGene1.0st)   10515714 (MoGene1.0st)   10515716 (MoGene1.0st)   10515729 (MoGene1.0st)   10515731 (MoGene1.0st)   10515733 (MoGene1.0st)   10515735 (MoGene1.0st)   10515737 (MoGene1.0st)   10515739 (MoGene1.0st)   1435279_at (Mouse Genome 430 2.0 Array)   1440819_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139348
Ensembl peptide - ENSMUSP00000074862
NCBI entrez gene - 230676     See in Manteia.
MGI - MGI:3033336
RefSeq - NM_198170
RefSeq Peptide - NP_937813
swissprot - A2A9C3
swissprot - V9GXW1
Ensembl - ENSMUSG00000033253
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01056637.1ENSDARG00000100203Danio rerio
 SZT2ENSGALG00000028561Gallus gallus
 SZT2ENSG00000198198Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0021540 corpus callosum morphogenesis IEA
 biological_processGO:0031667 response to nutrient levels IMP
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0042149 cellular response to glucose starvation IEA
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0061462 protein localization to lysosome IEA
 biological_processGO:1901668 regulation of superoxide dismutase activity IMP
 biological_processGO:1904262 negative regulation of TORC1 signaling IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane ISO
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0061700 GATOR2 complex IEA
 cellular_componentGO:0140007 KICSTOR complex IEA
 cellular_componentGO:1990130 GATOR1 complex IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Szt2Gt(XH662)Byg/Szt2Gt(XH662)Byg
Genetic Background: 129S1.129P2(B6)-Szt2Gt(XH662)Byg/FrkJ

 MP:0001499 kindling "long-lasting epileptogenic changes induced by daily sub threshold electrical brain stimulation, induced model for epilepsy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45446]
Show

Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002193 minimal clonic seizures "seizures involving rhythmic face and forelimb clonus including arm movement, and it may include rearing and falling and ventral flexion of the neck; a seizure is scored as minimal when it satisfies the minimal criteria up to or including ventral flexion, but does not include maximal tonic hindlimb extension" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, wf:Wayne Frankel , TJL staff]
Show

Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Szt2m1Frk/Szt2m1Frk
Genetic Background: involves: BALB/cByJ * C57BL/6J

Allelic Composition: Szt2Gt(XH662)Byg/Szt2Gt(XH662)Byg
Genetic Background: 129S1.129P2(B6)-Szt2Gt(XH662)Byg/FrkJ

Allelic Composition: Szt2Gt(XH662)Byg/Szt2m1Frk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Szt2Gt(XH662)Byg/Szt2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002194 maximal tonic hindlimb extension seizures "seizures induced by electrical stimulation of the brainstem; manifesting as a tonic-clonic flexion/extension sequence, starting in tonic extension of the forelimbs and terminating in a full tonic hindlimb extension, which is defined when the angle of the hindlimbs to the torso exceeds 90 degrees (although it is usually 180 degrees)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, wf:Wayne Frankel , TJL staff]
Show

Allelic Composition: Szt2m1Frk/Szt2m1Frk
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Szt2m1Frk/Szt2m1Frk
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Szt2m1Frk/Szt2m1Frk
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Szt2Gt(XH662)Byg/Szt2Gt(XH662)Byg
Genetic Background: 129S1.129P2(B6)-Szt2Gt(XH662)Byg/FrkJ

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Szt2Gt(XH662)Byg/Szt2m1Frk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Szt2Gt(XH662)Byg/Szt2Gt(XH662)Byg
Genetic Background: 129S1.129P2(B6)-Szt2Gt(XH662)Byg/FrkJ

Allelic Composition: Szt2Gt(XH662)Byg/Szt2Gt(XH662)Byg
Genetic Background: (B6.129P2-Szt2Gt(XH662)Byg x 129S1.129P2-Szt2Gt(XH662)Byg)F1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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