ENSMUSG00000033458


Mus musculus

Features
Gene ID: ENSMUSG00000033458
  
Biological name :Fan1
  
Synonyms : Fan1 / Fanconi-associated nuclease 1 / Q69ZT1
  
Possible biological names infered from orthology : FANCD2 and FANCI associated nuclease 1 / Q9Y2M0
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: C
Gene start: 64346758
Gene end: 64374095
  
Corresponding Affymetrix probe sets: 10564294 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000130012
NCBI entrez gene - 330554     See in Manteia.
MGI - MGI:3045266
RefSeq - NM_177893
RefSeq - XM_006540958
RefSeq Peptide - NP_808561
swissprot - Q69ZT1
Ensembl - ENSMUSG00000033458
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fan1ENSDARG00000062269Danio rerio
 FAN1ENSG00000198690Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR014883  VRR-NUC domain
 IPR033315  Fanconi-associated nuclease 1-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0006281 DNA repair ISO
 biological_processGO:0006289 nucleotide-excision repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0033683 nucleotide-excision repair, DNA incision IEA
 biological_processGO:0036297 interstrand cross-link repair IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0045171 intercellular bridge IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0004528 phosphodiesterase I activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008409 5"-3" exonuclease activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016788 hydrolase activity, acting on ester bonds IEA
 molecular_functionGO:0017108 5"-flap endonuclease activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070336 flap-structured DNA binding IEA
 molecular_functionGO:0140036 ubiquitin-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rcor2tm1c(EUCOMM)Wtsi/Rcor2tm1c(EUCOMM)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

Allelic Composition: Fan1tm1d(KOMP)Wtsi/Fan1tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rcor2tm1c(EUCOMM)Wtsi/Rcor2tm1c(EUCOMM)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fan1tm1d(KOMP)Wtsi/Fan1tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0003325 decreased liver function "reduced normal function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fan1tm1d(KOMP)Wtsi/Fan1tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rcor2tm1c(EUCOMM)Wtsi/Rcor2tm1c(EUCOMM)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

Allelic Composition: Fan1tm1d(KOMP)Wtsi/Fan1tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fan1tm1d(KOMP)Wtsi/Fan1tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rcor2tm1c(EUCOMM)Wtsi/Rcor2tm1c(EUCOMM)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rcor2tm1c(EUCOMM)Wtsi/Rcor2tm1c(EUCOMM)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

Allelic Composition: Fan1tm1.1Jrou/Fan1tm1.1Jrou,Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex
Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd

Allelic Composition: Fan1tm1.1Jrou/Fan1tm1.1Jrou,Slx4tm1.2Jrou/Slx4tm1.2Jrou
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fan1tm1.1Jrou/Fan1tm1.1Jrou,Slx1btm1.1Jrou/Slx1btm1.1Jrou
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fan1tm1d(KOMP)Wtsi/Fan1tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N

Allelic Composition: Fan1tm1d(KOMP)Wtsi/Fan1tm1d(KOMP)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N

Allelic Composition: Fan1tm1d(KOMP)Wtsi/Fan1tm1d(KOMP)Wtsi,Mus81tm1Chmg/Mus81tm1Chmg
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N * FVB/N

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rcor2tm1c(EUCOMM)Wtsi/Rcor2tm1c(EUCOMM)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fan1tm1d(KOMP)Wtsi/Fan1tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fan1tm1d(KOMP)Wtsi/Fan1tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0011346 renal tubule atrophy "acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rcor2tm1c(EUCOMM)Wtsi/Rcor2tm1c(EUCOMM)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0020427 increased hepatocyte karyomegaly "an increase in the number or proportion of liver cells with enlarged nuclei" [PMID:22733568, PMID:26980189, PMID:7731963, PMID:8701981, url:http://medical-dictionary.thefreedictionary.com/karyomegaly]
Show

Allelic Composition: Fan1tm1d(KOMP)Wtsi/Fan1tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000033458 Fan1 / Q69ZT1 / Fanconi-associated nuclease 1 / Q9Y2M0* / FANCD2 and FANCI associated nuclease 1*  / complex






 

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