ENSMUSG00000033487


Mus musculus

Features
Gene ID: ENSMUSG00000033487
  
Biological name :Fndc3a
  
Synonyms : Fibronectin type-III domain-containing protein 3A / Fndc3a / Q8BX90
  
Possible biological names infered from orthology : fibronectin type III domain containing 3A / Q9Y2H6
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D2
Gene start: 72537946
Gene end: 72710003
  
Corresponding Affymetrix probe sets: 10421488 (MoGene1.0st)   1426903_at (Mouse Genome 430 2.0 Array)   1443863_at (Mouse Genome 430 2.0 Array)   1458524_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000086411
Ensembl peptide - ENSMUSP00000124218
Ensembl peptide - ENSMUSP00000124637
NCBI entrez gene - 319448     See in Manteia.
MGI - MGI:1196463
RefSeq - XM_017316055
RefSeq - NM_207636
RefSeq - XM_006519115
RefSeq - XM_006519116
RefSeq - XM_006519118
RefSeq Peptide - NP_997519
swissprot - F6TLV3
swissprot - E0CXY0
swissprot - Q8BX90
Ensembl - ENSMUSG00000033487
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fndc3aENSDARG00000105503Danio rerio
 FNDC3AENSGALG00000017002Gallus gallus
 FNDC3AENSG00000102531Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6DFV6 / Fndc3c1 / Fibronectin type III domain containing protein 3C1 ENSMUSG0000003373742
Fndc3b / Mus musculus fibronectin type III domain containing 3B (Fndc3b), transcript variant 2, mRNA. / Q53EP0* / fibronectin type III domain containing 3B*ENSMUSG0000003928638
Fnd3c2ENSMUSG0000007301232


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0060009 Sertoli cell development IMP
 biological_processGO:0098609 cell-cell adhesion IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0001669 acrosomal vesicle IDA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0012506 vesicle membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Ppp1r1btm1Aaf/Ppp1r1btm1Aaf
Genetic Background: Not Specified

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Olfr17tm5(rtTA)Rax/Olfr17+,Tg(tetO-Kcnj2,lacZ)1Gogo/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Fndc3aGt(RRP208)Byg/Fndc3asys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ppp1r1btm1Aaf/Ppp1r1btm1Aaf
Genetic Background: Not Specified

Allelic Composition: Fndc3asys/Fndc3asys
Genetic Background: B6.Cg-Fndc3asys

Allelic Composition: Fndc3aGt(RRP208)Byg/Fndc3asys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppp1r1btm1Aaf/Ppp1r1btm1Aaf
Genetic Background: Not Specified

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppp1r1btm1Aaf/Ppp1r1btm1Aaf
Genetic Background: Not Specified

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppp1r1btm1Aaf/Ppp1r1btm1Aaf
Genetic Background: Not Specified

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
Show

Allelic Composition: Ppp1r1btm1Aaf/Ppp1r1btm1Aaf
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr