ENSMUSG00000033610


Mus musculus

Features
Gene ID: ENSMUSG00000033610
  
Biological name :Pank1
  
Synonyms : Pank1 / pantothenate kinase 1 / Q8K4K6
  
Possible biological names infered from orthology : Q8TE04
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C1
Gene start: 34810894
Gene end: 34879455
  
Corresponding Affymetrix probe sets: 10467162 (MoGene1.0st)   1418715_at (Mouse Genome 430 2.0 Array)   1429813_at (Mouse Genome 430 2.0 Array)   1429814_at (Mouse Genome 430 2.0 Array)   1431028_a_at (Mouse Genome 430 2.0 Array)   1457110_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043562
Ensembl peptide - ENSMUSP00000108079
NCBI entrez gene - 75735     See in Manteia.
MGI - MGI:1922985
RefSeq - XM_006527427
RefSeq - NM_001114339
RefSeq - NM_023792
RefSeq Peptide - NP_076281
RefSeq Peptide - NP_001107811
swissprot - Q543J7
swissprot - Q8K4K6
Ensembl - ENSMUSG00000033610
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pank1aENSDARG00000008192Danio rerio
 pank1bENSDARG00000010098Danio rerio
 PANK1ENSGALG00000006431Gallus gallus
 PANK1ENSG00000152782Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pank2 / Mus musculus pantothenate kinase 2 (Pank2), transcript variant 3, mRNA. / Q9BZ23* / pantothenate kinase 2*ENSMUSG0000003751456
Pank3 / Q8R2W9 / pantothenate kinase 3 / Q9H999*ENSMUSG0000001884652
Pank4 / Q80YV4 / Pantothenate kinase 4 / Q9NVE7*ENSMUSG000000290565


Protein motifs (from Interpro)
Interpro ID Name
 IPR004567  Type II pantothenate kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015937 coenzyme A biosynthetic process TAS
 biological_processGO:0016310 phosphorylation IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0030118 clathrin coat IDA
 cellular_componentGO:0055037 recycling endosome IDA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004594 pantothenate kinase activity IMP
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Coenzyme A biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000187 abnormal triglyceride level "anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccna2tm1.1Pisc/Ccna2tm1.1Pisc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccna2tm1.1Pisc/Ccna2tm1.1Pisc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Ccna2tm1.1Pisc/Ccna2tm1.1Pisc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccna2tm1.1Pisc/Ccna2tm1.1Pisc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccna2tm1.1Pisc/Ccna2tm1.1Pisc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccna2tm1.1Pisc/Ccna2tm1.1Pisc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
Show

Allelic Composition: Ccna2tm1.1Pisc/Ccna2tm1.1Pisc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005280 abnormal fatty acid level "anomalous concentration of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005323 dystonia "impairment of muscle tone resulting in prolonged muscle contraction and involuntary movements such as repetitive movements, or twisting or writhing of the limbs" [J:84533]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ccna2tm1.1Pisc/Ccna2tm1.1Pisc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccna2tm1.1Pisc/Ccna2tm1.1Pisc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccna2tm1.1Pisc/Ccna2tm1.1Pisc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccna2tm1.1Pisc/Ccna2tm1.1Pisc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccna2tm1.1Pisc/Ccna2tm1.1Pisc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccna2tm1.1Pisc/Ccna2tm1.1Pisc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Akap5tm1.1Jsco/Akap5tm1.1Jsco
Genetic Background: involves: 129S * C57BL/6

 MP:0014172 decreased fatty acid oxidation 
Show

Allelic Composition: Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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