ENSMUSG00000037514


Mus musculus

Features
Gene ID: ENSMUSG00000037514
  
Biological name :Pank2
  
Synonyms : Mus musculus pantothenate kinase 2 (Pank2), transcript variant 3, mRNA. / Pank2
  
Possible biological names infered from orthology : pantothenate kinase 2 / Q9BZ23
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F1
Gene start: 131262495
Gene end: 131299188
  
Corresponding Affymetrix probe sets: 10476287 (MoGene1.0st)   1431948_a_at (Mouse Genome 430 2.0 Array)   1443846_x_at (Mouse Genome 430 2.0 Array)   1452733_at (Mouse Genome 430 2.0 Array)   1458358_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139259
Ensembl peptide - ENSMUSP00000115034
Ensembl peptide - ENSMUSP00000119606
Ensembl peptide - ENSMUSP00000138992
Ensembl peptide - ENSMUSP00000139197
Ensembl peptide - ENSMUSP00000139203
NCBI entrez gene - 74450     See in Manteia.
MGI - MGI:1921700
RefSeq - XM_017319300
RefSeq - NM_001355681
RefSeq - NM_001355682
RefSeq - NM_153501
RefSeq - XM_006500298
RefSeq - XM_006500299
RefSeq - XM_006500300
RefSeq - XM_017319298
RefSeq - XM_017319299
RefSeq Peptide - NP_705721
RefSeq Peptide - NP_001342610
RefSeq Peptide - NP_001342611
swissprot - F6VV40
swissprot - Q3U4S0
swissprot - V9GXK8
swissprot - V9GX56
swissprot - V9GXL0
swissprot - V9GXP9
Ensembl - ENSMUSG00000037514
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PANK2ENSGALG00000015978Gallus gallus
 PANK2ENSG00000125779Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pank1 / Q8K4K6 / pantothenate kinase 1 / Q8TE04*ENSMUSG0000003361069
Pank3 / Q8R2W9 / pantothenate kinase 3 / Q9H999*ENSMUSG0000001884666
Pank4 / Q80YV4 / Pantothenate kinase 4 / Q9NVE7*ENSMUSG000000290566


Protein motifs (from Interpro)
Interpro ID Name
 IPR004567  Type II pantothenate kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0009060 aerobic respiration IMP
 biological_processGO:0015937 coenzyme A biosynthetic process IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019217 regulation of fatty acid metabolic process ISO
 biological_processGO:0051881 regulation of mitochondrial membrane potential IMP
 biological_processGO:0070584 mitochondrion morphogenesis IMP
 biological_processGO:0090207 regulation of triglyceride metabolic process ISO
 biological_processGO:1904251 regulation of bile acid metabolic process ISO
 cellular_componentGO:0005739 mitochondrion IMP
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0004594 pantothenate kinase activity IMP
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
Coenzyme A biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

Allelic Composition: Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

Allelic Composition: Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0002638 abnormal pupillary reflex "alterations or failure of the pupil to change in diamater as a reflex response to any stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

Allelic Composition: Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005280 abnormal fatty acid level "anomalous concentration of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005323 dystonia "impairment of muscle tone resulting in prolonged muscle contraction and involuntary movements such as repetitive movements, or twisting or writhing of the limbs" [J:84533]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0008455 abnormal retinal rod cell inner segment morphology "any structural anomaly of the retinal rod cell region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0008456 abnormal retinal rod cell outer segment morphology "any strucutral anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Akap5tm1.1Jsco/Akap5tm1.1Jsco
Genetic Background: involves: 129S * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0014172 decreased fatty acid oxidation 
Show

Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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