ENSMUSG00000034118


Mus musculus

Features
Gene ID: ENSMUSG00000034118
  
Biological name :Tpst1
  
Synonyms : O70281 / protein-tyrosine sulfotransferase 1 / Tpst1
  
Possible biological names infered from orthology : O60507 / tyrosylprotein sulfotransferase 1
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G1.3
Gene start: 130073326
Gene end: 130135729
  
Corresponding Affymetrix probe sets: 10526120 (MoGene1.0st)   1421733_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035614
Ensembl peptide - ENSMUSP00000112571
Ensembl peptide - ENSMUSP00000119880
NCBI entrez gene - 22021     See in Manteia.
MGI - MGI:1298231
RefSeq - XM_006504418
RefSeq - NM_001130476
RefSeq - NM_013837
RefSeq Peptide - NP_001123948
RefSeq Peptide - NP_038865
swissprot - O70281
swissprot - Q4FK50
swissprot - D3Z1F4
Ensembl - ENSMUSG00000034118
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tpst1ENSDARG00000073872Danio rerio
 TPST1ENSGALG00000002598Gallus gallus
 TPST1ENSG00000169902Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tpst2 / protein-tyrosine sulfotransferase 2 / O60704* / tyrosylprotein sulfotransferase 2*ENSMUSG0000002934465


Protein motifs (from Interpro)
Interpro ID Name
 IPR026634  Protein-tyrosine sulfotransferase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006478 peptidyl-tyrosine sulfation IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030173 integral component of Golgi membrane IEA
 molecular_functionGO:0008476 protein-tyrosine sulfotransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Cytosolic sulfonation of small molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000033152 Podxl2 / Mus musculus podocalyxin-like 2 (Podxl2), transcript variant 1, mRNA. / Q9NZ53* / podocalyxin like 2*  / reaction






 

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contact: otassy@igbmc.fr