ENSMUSG00000029344


Mus musculus

Features
Gene ID: ENSMUSG00000029344
  
Biological name :Tpst2
  
Synonyms : protein-tyrosine sulfotransferase 2 / Tpst2
  
Possible biological names infered from orthology : O60704 / tyrosylprotein sulfotransferase 2
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 112276691
Gene end: 112315361
  
Corresponding Affymetrix probe sets: 10524345 (MoGene1.0st)   1416086_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116816
Ensembl peptide - ENSMUSP00000142679
Ensembl peptide - ENSMUSP00000031287
Ensembl peptide - ENSMUSP00000071399
Ensembl peptide - ENSMUSP00000114592
NCBI entrez gene - 22022     See in Manteia.
MGI - MGI:1309516
RefSeq - XM_006534849
RefSeq - XM_017320800
RefSeq - XM_006534850
RefSeq - NM_001326590
RefSeq - NM_009419
RefSeq Peptide - NP_001313519
RefSeq Peptide - NP_033445
swissprot - Q3TQN1
swissprot - D3YV96
swissprot - A0A0G2JE92
swissprot - F7BM44
Ensembl - ENSMUSG00000029344
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tpst2ENSDARG00000099155Danio rerio
 TPST2ENSGALG00000005626Gallus gallus
 TPST2ENSG00000128294Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tpst1 / O70281 / protein-tyrosine sulfotransferase 1 / O60507* / tyrosylprotein sulfotransferase 1*ENSMUSG0000003411862


Protein motifs (from Interpro)
Interpro ID Name
 IPR026634  Protein-tyrosine sulfotransferase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006478 peptidyl-tyrosine sulfation IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 molecular_functionGO:0008476 protein-tyrosine sulfotransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Cytosolic sulfonation of small molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003503 decreased activity of thyroid 
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003968 abnormal growth hormone level 
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004163 abnormal adenophysis morphology "any malformation or absence of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008366 enlarged adenohypophysis "increased size of the anterior part of the pituitary that secretes a variety of hormones" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000033152 Podxl2 / Mus musculus podocalyxin-like 2 (Podxl2), transcript variant 1, mRNA. / Q9NZ53* / podocalyxin like 2*  / reaction






 

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