ENSMUSG00000034248


Mus musculus

Features
Gene ID: ENSMUSG00000034248
  
Biological name :Slc25a37
  
Synonyms : Q920G8 / Slc25a37 / solute carrier family 25, member 37
  
Possible biological names infered from orthology : Q9NYZ2
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D2
Gene start: 69241848
Gene end: 69285112
  
Corresponding Affymetrix probe sets: 10421172 (MoGene1.0st)   1417750_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039990
Ensembl peptide - ENSMUSP00000139104
Ensembl peptide - ENSMUSP00000139178
NCBI entrez gene - 67712     See in Manteia.
MGI - MGI:1914962
RefSeq - NM_026331
RefSeq - XM_006519461
RefSeq Peptide - NP_080607
swissprot - J3QPY4
swissprot - Q920G8
Ensembl - ENSMUSG00000034248
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q287T7ENSDARG00000073743Danio rerio
 SLC25A37ENSGALG00000000378Gallus gallus
 Q9NYZ2ENSG00000147454Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8R0Z5 / Slc25a28 / solute carrier family 25, member 28 / Q96A46*ENSMUSG0000004041463
Q920G8 / Gm16867 / Mitoferrin-1 ENSMUSG0000009395422


Protein motifs (from Interpro)
Interpro ID Name
 IPR018108  Mitochondrial substrate/solute carrier
 IPR023395  Mitochondrial carrier domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006839 mitochondrial transport IBA
 biological_processGO:0048250 iron import into the mitochondrion IMP
 biological_processGO:0055072 iron ion homeostasis IBA
 biological_processGO:1903874 ferrous iron transmembrane transport IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 molecular_functionGO:0005381 iron ion transmembrane transporter activity IMP
 molecular_functionGO:0015093 ferrous iron transmembrane transporter activity EXP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gata2tm4.1Sho/Gata2tm4.1Sho
Genetic Background: Not Specified

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Gata2tm4.1Sho/Gata2tm4.1Sho
Genetic Background: Not Specified

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Gata2tm4.1Sho/Gata2tm4.1Sho
Genetic Background: Not Specified

 MP:0000610 cholestasis "impairment of bile flow due to obstruction in small bile ducts (intrahepatic cholestasis) or obstruction in large bile ducts (extrahepatic cholestasis)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc25a37tm1.1Kapl/Slc25a37tm1.2Kapl,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * DBA

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Gata2tm4.1Sho/Gata2tm4.1Sho
Genetic Background: Not Specified

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gata2tm4.1Sho/Gata2tm4.1Sho
Genetic Background: Not Specified

Allelic Composition: Slc25a37tm1.1Kapl/Slc25a37tm1.2Kapl,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * DBA

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Gata2tm4.1Sho/Gata2tm4.1Sho
Genetic Background: Not Specified

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata2tm4.1Sho/Gata2tm4.1Sho
Genetic Background: Not Specified

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gata2tm4.1Sho/Gata2tm4.1Sho
Genetic Background: Not Specified

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gata2tm4.1Sho/Gata2tm4.1Sho
Genetic Background: Not Specified

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata2tm4.1Sho/Gata2tm4.1Sho
Genetic Background: Not Specified

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata2tm4.1Sho/Gata2tm4.1Sho
Genetic Background: Not Specified

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata2tm4.1Sho/Gata2tm4.1Sho
Genetic Background: Not Specified

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Slc25a37tm1.1Kapl/Slc25a37tm1.2Kapl,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * DBA

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gata2tm4.1Sho/Gata2tm4.1Sho
Genetic Background: Not Specified

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata2tm4.1Sho/Gata2tm4.1Sho
Genetic Background: Not Specified

 MP:0005637 abnormal iron homeostasis "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64456]
Show

Allelic Composition: Slc25a37tm1.1Kapl/Slc25a37tm1.2Kapl,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * DBA

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata2tm4.1Sho/Gata2tm4.1Sho
Genetic Background: Not Specified

 MP:0008956 decreased cellular hemoglobin content "decrease in the mean of the red blood cell hemoglobin concentration (RBC CH) histogram, which represents the distribution of red blood cells by the amount of hemoglobin present in each individual cell independent of cell volume" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata2tm4.1Sho/Gata2tm4.1Sho
Genetic Background: Not Specified

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Gata2tm4.1Sho/Gata2tm4.1Sho
Genetic Background: Not Specified

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Gata2tm4.1Sho/Gata2tm4.1Sho
Genetic Background: Not Specified

 MP:0011178 increased erythroblast number "greater number of the nucleated precursor of erythrocytes" [MGI:csmith]
Show

Allelic Composition: Gata2tm4.1Sho/Gata2tm4.1Sho
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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