Manteia

ENSMUSG00000034269

Mus musculus

Features

Gene ID:	ENSMUSG00000034269

Biological name :	Setd5

Synonyms :	Mus musculus SET domain containing 5 (Setd5), transcript variant 2, mRNA. / Q5XJV7 / Setd5

Possible biological names infered from orthology :	Q9C0A6 / SET domain containing 5

Species:	Mus musculus

Chr. number:	6
Strand:	1
Band:	E3
Gene start:	113077365
Gene end:	113153435

Corresponding Affymetrix probe sets:	10540554 (MoGene1.0st) 1437206_at (Mouse Genome 430 2.0 Array) 1439515_at (Mouse Genome 430 2.0 Array) 1441125_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000047398 Ensembl peptide - ENSMUSP00000108780 Ensembl peptide - ENSMUSP00000108782 NCBI entrez gene - 72895 See in Manteia. MGI - MGI:1920145 RefSeq - XM_017321772 RefSeq - NM_028385 RefSeq - NM_173005 RefSeq - XM_017321769 RefSeq - XM_017321770 RefSeq - XM_017321771 RefSeq - XM_006506677 RefSeq - XM_011241480 RefSeq - XM_011241482 RefSeq - XM_011241484 RefSeq - XM_011241485 RefSeq - XM_017321767 RefSeq - XM_017321768 RefSeq Peptide - NP_766593 RefSeq Peptide - NP_082661 swissprot - Q5XJV7 Ensembl - ENSMUSG00000034269

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
setd5	ENSDARG00000078576	Danio rerio
SETD5	ENSGALG00000006571	Gallus gallus
SETD5	ENSG00000168137	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Kmt2e / Q3UG20 / Histone-lysine N-methyltransferase 2E / Q8IZD2* / lysine methyltransferase 2E*	ENSMUSG00000029004	34

Protein motifs (from Interpro)

Interpro ID	Name
IPR001214	SET domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006325	chromatin organization	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0016569	covalent chromatin modification	IMP
biological_process	GO:0035065	regulation of histone acetylation	IMP
biological_process	GO:1902275	regulation of chromatin organization	IMP
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	ISO
cellular_component	GO:0016593	Cdc73/Paf1 complex	IDA
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000220	increased monocyte count	"greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000284	double outlet right ventricle	"both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000438	abnormal skull morphology	"anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000443	abnormal snout morphology	"anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000455	abnormal maxilla morphology	"malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000480	increased number of ribs	"greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000602	enlarged sinusoidal spaces	"larger than normal sized cavities in the liver " [J:23170]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000632	abnormal pineal gland morphology	"anomalous structure of the small, flattened body located in the depression between the superior colliculi and which produces melatonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000703	abnormal thymus morphology	"anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000706	small thymus	"reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000783	abnormal forebrain morphology	"malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000819	abnormal olfactory bulb morphology	"malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000841	abnormal hindbrain morphology	"malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0001015	small superior cervical ganglion	"reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:23882]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0002075	abnormal coat color	"irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0002100	abnormal tooth morphology	"atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0002633	persistent truncus arteriosis	"complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0002951	small thyroid gland	"reduced size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0002989	small kidney	"reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0003047	abnormal thoracic vertebrae morphology	"malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0003048	abnormal cervical vertebrae morphology	"malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0003686	abnormal eye muscle morphology	"malformation of the muscles of the eye" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0004158	right aortic arch	"the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0004201	fetal growth retardation	"slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0004268	abnormal optic stalk morphology	"any structural anomaly of the narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain" [ISBN:0-914294-08-3 "Gray s Anatomy"]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0004269	abnormal optic cup morphology	"any structural anomaly of double walled stuctured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0004609	vertebral fusion	"the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0004613	fusion of vertebral arches	"improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0004646	decreased cervical vertebrae number	"reduced number of the seven bony segments of the spine located anterior to the thoracic vertebrae and caudal to the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0004651	increased thoracic vertebrae number	"increased number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0006064	abnormal superior vena cava morphology	"structural malformation in the principal vein draining blood from the upper portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0006358	absent pinna reflex	"complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0008922	abnormal cervical rib	"alternate location or appearance of a rare supernumerary rib commonly articulating with the seventh cervical vertebrae (above the normal first rib) but not reaching the sternum anteriorly" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0010053	decreased grip strength	"reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0010168	increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	"a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0010200	enlarged lymphatic vessel	"increased size of the network of vessels which carries lymph around the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0010403	atrial septal defect	"abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0010418	perimembraneous ventricular septal defect	"abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0010420	muscular ventricular septal defect	"abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0010433	double inlet heart left ventricle	"congenital heart defect in which both atriums are connected to the left ventricle, with a hypoplastic right ventricle often present, which may be on the opposite side of the heart to the usua" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0010436	abnormal coronary sinus morphology	"any structural anomaly of the short trunk that recieves most of the cardiac veins carrying the blood from the myocardium and delivers it to the right atrium, with the sinoatrial connection occuring between the inferior vena cava and the atrioventricular orifice" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0010484	bicuspid aortic valve	"the presence of two cusps in the aortic valve instead of three" [http://emedicine.medscape.com]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0010572	persistent right dorsal aorta	"persistence of the right dorsal aorta after development; the right dorsal aorta normally regresses but when it persists, a double aortic arch develops; if the left dorsal aorta also regresses, a right aortic arch forms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0010595	abnormal aortic valve cusp morphology	"any structural anomaly of the three fibrous triangular components and associated flap of the aortic valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0011683	dual inferior vena cava	"presence of two inferior vena cavae, often resulting from the persistence of both supracardinal veins during development; the two structures may be symmetric or asymmetric but typically join together at the renal vein" [MGI:csmith, PMID:10835118]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0012767	increased KLRG1-positive NK cell number	"increase in the number of KLRG1 positive NK cells that represent a maturation subset of NK cells and is linked to NK cell proliferation" [MGI:Annie_Speak, PMID:19479342]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013023	decreased Ly6C high monocyte number	"decrease in the number of monocytes that express high levels of Ly6C and low MHC class II that represent a subset of circulating inflammatory monocytes that are recruited to infected or inflamed tissues" [MGI:Annie_Speak]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013025	increased Ly6C low monocyte number	"increase in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [MGI:Annie_Speak]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013809	absent pectinate muscle	"absence of the prominent ridges of atrial myocardium located on the inner surface of most of the right atrium and both the right and left auricular regions" [ISBN:0-683-40008-8]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013810	absent brachiocephalic trunk	"absence of the short first aortic arch branch which divides into the right subclavian artery and the right common carotid artery" [MGI:csmith]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013812	enlarged orbital veins	"increased size of the highly complex and variable set of veins that drain blood from the eye and supporting tissue, including the superior and inferior ophthalmic veins, the middle and medial ophthalmic veins, four collateral veins), variable orbital venous networks, and variable venous tributaries" [PMID:17019411]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013813	dilated hepatic portal vein	"an expansion in the lumen volume of the wide short vein formed from the confluence of the superior mesenteric, inferior mesenteric and splenic veins, which then divides into the right and left branches which ramify with the liver" [ISBN:0-683-40008-8]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013814	abnormal hepatic portal vein connection	"any anomaly of the connection site of the right or left branch of the hepatic portal vein to the liver" [ISBN:0-683-40008-8]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013836	abnormal hypoglossal nerve topology	"abnormal position of the hypoglossal nerve " [MGI:csmith]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013840	absent segment of posterior cerebral artery	"absence of a portion of one of a pair of blood vessels that supplies oxygenated blood to the posterior aspect of the brain" [UBERON:0001636]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013842	ductus venosus stenosis	"narrowing of the lumen of the embryonic connection between the portal vein and inferior vena cava formed by the left umbilical vein that allows oxygenated blood to bypass the developing liver during the time when this connection is normally open; this normally closes during develpment to adulthood" [MGI:csmith]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013848	subcutaneous edema	"accumulation of watery or serous fluid in the subcutaneous region below the skin" [MGI:csmith]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013859	abnormal vitelline vein connection	"aberrant or missing attachment of the paired veins that carry blood from the yolk sac back to the embryo" [ISBN:0-683-40008-8, MGI:csmith]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013864	enlarged paraumbilical vein	"increased size of one or more of small superficial veins that run from the umbilicus along the round ligament of the liver and terminate as accessory portal veins in the liver" [ISBN:0-683-40008-8, PMID:7400038]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013874	abnormal ductus venosus topology	"aberrant position or orientation of the embryonic connection between the portal vein and inferior vena cava formed by the left umbilical vein that allows oxygenated blood to bypass the developing liver during the time when this connection is normally open; this normally closes during develpment to adulthood" [MGI:csmith]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013876	absent ductus venosus valve	"absence of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013878	abnormal ductus venosus valve topology	"abnormal position of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013948	intraembryonal intestine elongation		Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013969	reduced sympathetic cervical ganglion size		Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013971	blood in lymph vessels		Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013977	symmetric azygos veins		Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013986	abnormal vitelline vein topology	"abnormal position of the paired veins that carry blood from the yolk sac back to the embryo" [MGI:csmith]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0014000	anastomosis between internal carotid artery and basilar artery		Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0014001	abnormal vertebral artery topology	"abnormal position of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [MGI:csmith]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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