ENSMUSG00000034341


Mus musculus

Features
Gene ID: ENSMUSG00000034341
  
Biological name :Wbp2
  
Synonyms : P97765 / Wbp2 / WW domain binding protein 2
  
Possible biological names infered from orthology : Q969T9
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 116078573
Gene end: 116086995
  
Corresponding Affymetrix probe sets: 10393098 (MoGene1.0st)   1448121_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000074204
Ensembl peptide - ENSMUSP00000102052
NCBI entrez gene - 22378     See in Manteia.
MGI - MGI:104709
RefSeq - XM_006533167
RefSeq - NM_016852
RefSeq Peptide - NP_058548
RefSeq Peptide - NP_001334571
swissprot - P97765
swissprot - Q544A1
Ensembl - ENSMUSG00000034341
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wbp2ENSDARG00000056605Danio rerio
 WBP2ENSGALG00000002219Gallus gallus
 WBP2ENSG00000132471Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9D529 / Wbp2nl / WBP2 N-terminal like / Q6ICG8*ENSMUSG0000002245534


Protein motifs (from Interpro)
Interpro ID Name
 IPR004182  GRAM domain
 IPR011993  PH-like domain superfamily
 IPR033598  WW domain-binding protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0032570 response to progesterone ISO
 biological_processGO:0033148 positive regulation of intracellular estrogen receptor signaling pathway ISS
 biological_processGO:0043627 response to estrogen ISO
 biological_processGO:0045184 establishment of protein localization ISO
 biological_processGO:0045815 positive regulation of gene expression, epigenetic ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0050847 progesterone receptor signaling pathway ISO
 biological_processGO:0071391 cellular response to estrogen stimulus ISO
 biological_processGO:0071442 positive regulation of histone H3-K14 acetylation ISO
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003713 transcription coactivator activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030331 estrogen receptor binding ISO
 molecular_functionGO:0031490 chromatin DNA binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bap1em3Test/Bap1+
Genetic Background: involves: FVB

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Wbp2tm2a(EUCOMM)Wtsi/Wbp2tm2a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Wbp2tm2a(EUCOMM)Wtsi/Cnrm

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

Allelic Composition: Wbp2tm2a(EUCOMM)Wtsi/Wbp2tm2a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Wbp2tm2a(EUCOMM)Wtsi/Cnrm

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bap1em3Test/Bap1+
Genetic Background: involves: FVB

 MP:0004740 sensorineural hearing loss "a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bap1em3Test/Bap1+
Genetic Background: involves: FVB

 MP:0004746 abnormal cochlear IHC afferent innervation "any changes in the morphology or number of afferent terminals and/or their synapses in the cochlear IHC region" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bap1em3Test/Bap1+
Genetic Background: involves: FVB

 MP:0004747 abnormal cochlear OHC afferent innervation "any changes in the morphology or number of afferent terminals and/or their synapses in the cochlear OHC region" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bap1em3Test/Bap1+
Genetic Background: involves: FVB

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

Allelic Composition: Wbp2tm2a(EUCOMM)Wtsi/Wbp2tm2a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Wbp2tm2a(EUCOMM)Wtsi/Cnrm

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0006358 absent pinna reflex "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0006388 abnormal auditory summating potiential "any anomaly in the dc shift in the waveform sustained for the duration of a toneburst stimulus that represents the depolarization of sensory hair cells in the cochlea; positive summating potentials (SPs) reflect activity of basal turn hair cells while negative SPs are derived from hair cell activity in the apical turn; negative SPs tend to be obtained at low frequencies and low intensities of stimulus, while positive SPs are recorded in response to high frequencies and high intensities " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1526886]
Show

Allelic Composition: Bap1em3Test/Bap1+
Genetic Background: involves: FVB

 MP:0008805 decreased circulating amylase level "reduction in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bap1em3Test/Bap1+
Genetic Background: involves: FVB

 MP:0010088 decreased circulating fructosamine level "decrease in the concentration in the blood of total non enzymatic glycated proteins in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
Show

Allelic Composition: Bap1em3Test/Bap1+
Genetic Background: involves: FVB

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Bap1em3Test/Bap1+
Genetic Background: involves: FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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