Manteia - Molecule gene

ENSMUSG00000034579

Mus musculus

Features

Gene ID:	ENSMUSG00000034579

Biological name :	Pla2g3

Synonyms :	phospholipase A2, group III / Pla2g3

Possible biological names infered from orthology :	Q9NZ20

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	A1
Gene start:	3488284
Gene end:	3499350

Corresponding Affymetrix probe sets:	10373756 (MoGene1.0st) 1456231_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000041571 Ensembl peptide - ENSMUSP00000068699 NCBI entrez gene - 237625 See in Manteia. MGI - MGI:2444945 RefSeq - XM_017314511 RefSeq - NM_172791 RefSeq - XM_006514689 RefSeq - XM_006514690 RefSeq - XM_006514691 RefSeq Peptide - NP_766379 swissprot - Q8BV23 swissprot - Q8BZT7 Ensembl - ENSMUSG00000034579

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
CU459012.1	ENSDARG00000098989	Danio rerio
zgc:123275	ENSDARG00000008948	Danio rerio
	ENSGALG00000030512	Gallus gallus
PLA2G3	ENSG00000100078	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
B0QZF7 / Proca1 / Protein PROCA1 / Q8NCQ7* / protein interacting with cyclin A1*	ENSMUSG00000044122	5

Protein motifs (from Interpro)

Interpro ID	Name
IPR016090	Phospholipase A2 domain
IPR033113	Phospholipase A2, histidine active site
IPR036444	Phospholipase A2 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001675	acrosome assembly	IMP
biological_process	GO:0006644	phospholipid metabolic process	IEA
biological_process	GO:0007288	sperm axoneme assembly	IMP
biological_process	GO:0019372	lipoxygenase pathway	IMP
biological_process	GO:0043303	mast cell degranulation	IMP
biological_process	GO:0046470	phosphatidylcholine metabolic process	IMP
biological_process	GO:0048468	cell development	IMP
biological_process	GO:0050482	arachidonic acid secretion	IEA
biological_process	GO:0060271	cilium assembly	ISO
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005814	centriole	ISO
cellular_component	GO:0042629	mast cell granule	IEA
molecular_function	GO:0003674	molecular_function	ND
molecular_function	GO:0004623	phospholipase A2 activity	IEA

Pathways (from Reactome)

Pathway description

Acyl chain remodelling of PC

Acyl chain remodelling of PE

Acyl chain remodelling of PG

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000242	impaired fertilization	"defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J
MP:0000359	abnormal mast cell morphology	"anomalous structure of these granulated cells found in most tissues, but most abundantly in skin and g.i. tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Kit^W-sh/Kit^W-sh Genetic Background: involves: C57BL/6J
MP:0001785	edema	"an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]	Show Allelic Composition: Kit^W-sh/Kit^W-sh Genetic Background: involves: C57BL/6J
MP:0001849	ear inflammation	"local accumulation of fluid, plasma proteins and leukocytes in the ear" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kit^W-sh/Kit^W-sh Genetic Background: involves: C57BL/6J
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J Allelic Composition: Pla2g3^tm1Murm/Pla2g3⁺ Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J Allelic Composition: Pla2g3^tm1Murm/Pla2g3⁺ Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0002660	abnormal caput	"anomalous structure of the head of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J
MP:0002686	globozoospermia	"malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J
MP:0003698	abnormal male reproductive system physiology	"anomaly in the function of the male organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J
MP:0004543	abnormal sperm physiology	"anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J
MP:0004777	abnormal phospholipid level	"anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J
MP:0005410	abnormal fertilization	"anomaly in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J
MP:0005462	abnormal mast cell morphology/development	"anomalous structure, development or number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Kit^W-sh/Kit^W-sh Genetic Background: involves: C57BL/6J
MP:0005535	abnormal body temperature	"deviation in the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kit^W-sh/Kit^W-sh Genetic Background: involves: C57BL/6J
MP:0005597	decreased susceptibility to type I hypersensitivity reaction	"less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kit^W-sh/Kit^W-sh Genetic Background: involves: C57BL/6J
MP:0006362	abnormal male germ cell morphology	"any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J
MP:0008765	decreased mast cell degranulation	"reduction in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kit^W-sh/Kit^W-sh Genetic Background: involves: C57BL/6J
MP:0008898	abnormal acrosome morphology	"any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J
MP:0009237	kinked sperm flagellum	"a sharp bend or zigzag in the sperm tail" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J
MP:0009238	coiled sperm flagellum	"abnormal twisting of the sperm flagellum into coils or spirals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J
MP:0009280	reduced activated sperm motility	"loss or reduction of the activated type of sperm mobility, resulting in immotile sperm that are generally unable to reach the uterotubal junction; decreases in activated sperm motility may result in reduced male fertility" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J Allelic Composition: Pla2g3^tm1Murm/Pla2g3⁺ Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0009647	decreased fertilization frequency	"he number of secondary oocytes each penetrated by a spermatozoon followed by fusion of the male and female pronuclei are fewer than expected" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J Allelic Composition: Pla2g3^tm1Murm/Pla2g3⁺ Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0009781	abnormal preimplantation embryo development	"an anomaly in the developmental progress of an embryo from 2 cell to blastocyst affecting the viability or number of embryos" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J
MP:0009838	abnormal sperm axoneme morphology	"any structural abnormality of the central core of the sperm flagellum, composed of a ring of 9 outer microtubule doublets surrounding a central pair; inner and outer dynein arms project from each of the outer 9 doublets, and these arms are responsible for generating the motive force of the flagellum; in addition, 9 radial spokes, each of which originates from 1 of the 9 outer microtubular doublet pairs, project inward toward the central pair in a helical fashion" [PMID:14581499]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J
MP:0009839	multiflagellated sperm	"presence of more than one sperm flagellum, displaying either one common origin from the sperm head or multiple origins from the same sperm head" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J
MP:0011094	complete embryonic lethality before implantation	"death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J Allelic Composition: Pla2g3^tm1Murm/Pla2g3⁺ Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0020451	decreased sperm progressive motility	"decrease in the ability of sperm to move in a more or less straight line" [MGI:smb]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J Allelic Composition: Pla2g3^tm1Murm/Pla2g3⁺ Genetic Background: involves: 129S/SvEv * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr