ENSMUSG00000034906


Mus musculus

Features
Gene ID: ENSMUSG00000034906
  
Biological name :Ncaph
  
Synonyms : Ncaph / non-SMC condensin I complex, subunit H / Q8C156
  
Possible biological names infered from orthology : Q15003
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F1
Gene start: 127103809
Gene end: 127133954
  
Corresponding Affymetrix probe sets: 10487340 (MoGene1.0st)   1423920_at (Mouse Genome 430 2.0 Array)   1436707_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106017
Ensembl peptide - ENSMUSP00000135620
NCBI entrez gene - 215387     See in Manteia.
MGI - MGI:2444777
RefSeq - NM_144818
RefSeq Peptide - NP_659067
swissprot - H3BL21
swissprot - Q8C156
Ensembl - ENSMUSG00000034906
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ncaphENSDARG00000061468Danio rerio
 NCAPHENSGALG00000032270Gallus gallus
 NCAPHENSG00000121152Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR022816  Condensin complex subunit 2/barren


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007076 mitotic chromosome condensation ISO
 biological_processGO:0010032 meiotic chromosome condensation IMP
 biological_processGO:0030261 chromosome condensation IEA
 biological_processGO:0045132 meiotic chromosome segregation IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity IEA
 cellular_componentGO:0000796 condensin complex ISO
 cellular_componentGO:0000799 nuclear condensin complex IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0044547 DNA topoisomerase binding IBA
 molecular_functionGO:0072587 DNA topoisomerase (ATP-hydrolyzing) activator activity IBA


Pathways (from Reactome)
Pathway description
Condensation of Prometaphase Chromosomes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic Background: NOD.B6-Mcph1Tg(HLA-A2.1)1Enge

Allelic Composition: Ncaphtm1.1Itl/Ncaphtm1.2Itl,Ncaph2tm1.1Itl/Ncaph2tm1.2Itl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ncaphtm1.1Itl/Ncaphtm1.2Itl,Ncaph2tm1.1Itl/Ncaph2tm1.2Itl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic Background: NOD.B6-Mcph1Tg(HLA-A2.1)1Enge

Allelic Composition: Ncaphtm1.1Itl/Ncaphtm1.2Itl,Ncaph2tm1.1Itl/Ncaph2tm1.2Itl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Ncaphtm1.1Itl/Ncaphtm1.2Itl,Ncaph2tm1.1Itl/Ncaph2tm1.2Itl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic Background: NOD.B6-Mcph1Tg(HLA-A2.1)1Enge

Allelic Composition: Ncaphtm1.1Itl/Ncaphtm1.2Itl,Ncaph2tm1.1Itl/Ncaph2tm1.2Itl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic Background: NOD.B6-Mcph1Tg(HLA-A2.1)1Enge

 MP:0012203 abnormal neuronal stem cell morphology "any structural anomaly of an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors" [CL:0000047]
Show

Allelic Composition: Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic Background: NOD.B6-Mcph1Tg(HLA-A2.1)1Enge

Allelic Composition: Ncaphtm1.1Itl/Ncaphtm1.2Itl,Ncaph2tm1.1Itl/Ncaph2tm1.2Itl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0012204 abnormal neuronal stem cell physiology "any functional anomaly of an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors" [CL:0000047]
Show

Allelic Composition: Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic Background: NOD.B6-Mcph1Tg(HLA-A2.1)1Enge

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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