ENSMUSG00000035198


Mus musculus

Features
Gene ID: ENSMUSG00000035198
  
Biological name :Tubg1
  
Synonyms : P83887 / Tubg1 / tubulin, gamma 1
  
Possible biological names infered from orthology : P23258
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 101119938
Gene end: 101126419
  
Corresponding Affymetrix probe sets: 10381250 (MoGene1.0st)   1417144_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048036
NCBI entrez gene - 103733     See in Manteia.
MGI - MGI:101834
RefSeq - XM_017314211
RefSeq - NM_134024
RefSeq Peptide - NP_598785
swissprot - P83887
swissprot - Q6F4J1
Ensembl - ENSMUSG00000035198
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tubg1ENSDARG00000015610Danio rerio
 ENSGALG00000030003Gallus gallus
 TUBG1ENSG00000131462Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tubg2 / Q8VCK3 / tubulin, gamma 2 / Q9NRH3*ENSMUSG0000004500796


Protein motifs (from Interpro)
Interpro ID Name
 IPR000217  Tubulin
 IPR002454  Gamma tubulin
 IPR003008  Tubulin/FtsZ, GTPase domain
 IPR008280  Tubulin/FtsZ, C-terminal
 IPR017975  Tubulin, conserved site
 IPR018316  Tubulin/FtsZ, 2-layer sandwich domain
 IPR036525  Tubulin/FtsZ, GTPase domain superfamily
 IPR037103  Tubulin/FtsZ, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000212 meiotic spindle organization IEP
 biological_processGO:0007017 microtubule-based process IEA
 biological_processGO:0007020 microtubule nucleation TAS
 biological_processGO:0007052 mitotic spindle organization TAS
 biological_processGO:0007088 regulation of mitotic nuclear division TAS
 biological_processGO:0031122 cytoplasmic microtubule organization IEA
 cellular_componentGO:0000242 pericentriolar material IDA
 cellular_componentGO:0000794 condensed nuclear chromosome IDA
 cellular_componentGO:0000922 spindle pole TAS
 cellular_componentGO:0000930 gamma-tubulin complex IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005814 centriole IDA
 cellular_componentGO:0005815 microtubule organizing center TAS
 cellular_componentGO:0005827 polar microtubule IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005876 spindle microtubule IDA
 cellular_componentGO:0005881 cytoplasmic microtubule IDA
 cellular_componentGO:0005929 cilium IDA
 cellular_componentGO:0031252 cell leading edge IDA
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:0045177 apical part of cell IDA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0097730 non-motile cilium IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Fgl2tm1Pam/Fgl2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: Fgl2tm1Pam/Fgl2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Fgl2tm1Pam/Fgl2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000759 P58854 / Tubgcp3 / tubulin, gamma complex associated protein 3 / Q96CW5*  / complex
 ENSMUSG00000025474 Q921G8 / Tubgcp2 / tubulin, gamma complex associated protein 2 / Q9BSJ2*  / complex
 ENSMUSG00000045007 Tubg2 / Q8VCK3 / tubulin, gamma 2 / Q9NRH3*  / complex






 

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