ENSMUSG00000035199


Mus musculus

Features
Gene ID: ENSMUSG00000035199
  
Biological name :Arl6ip5
  
Synonyms : Arl6ip5 / PRA1 family protein 3 / Q8R5J9
  
Possible biological names infered from orthology : ADP ribosylation factor like GTPase 6 interacting protein 5 / O75915
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: D3
Gene start: 97210689
Gene end: 97233315
  
Corresponding Affymetrix probe sets: 10540241 (MoGene1.0st)   1417225_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041503
NCBI entrez gene - 65106     See in Manteia.
MGI - MGI:1929501
RefSeq - NM_022992
RefSeq Peptide - NP_075368
swissprot - Q8R5J9
Ensembl - ENSMUSG00000035199
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arl6ip5aENSDARG00000077044Danio rerio
 arl6ip5bENSDARG00000016238Danio rerio
 Q5F433ENSGALG00000038904Gallus gallus
 O75915ENSG00000144746Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Praf2 / Q9JIG8 / PRA1 family protein 2 / O60831* / PRA1 domain family member 2*ENSMUSG0000003114941


Protein motifs (from Interpro)
Interpro ID Name
 IPR004895  Prenylated rab acceptor PRA1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002037 negative regulation of L-glutamate import across plasma membrane IDA
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IEA
 biological_processGO:0010917 negative regulation of mitochondrial membrane potential IEA
 biological_processGO:0015813 L-glutamate transmembrane transport IDA
 biological_processGO:0032874 positive regulation of stress-activated MAPK cascade IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Glutamate Neurotransmitter Release Cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Arl6ip5tm1.2Jwzh/Arl6ip5tm1.2Jwzh
Genetic Background: B6.129X1-Arl6ip5tm1.2Jwzh

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arl6ip5tm1.2Jwzh/Arl6ip5tm1.2Jwzh
Genetic Background: B6.129X1-Arl6ip5tm1.2Jwzh

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Col27a1tm1.1Rpbh/Col27a1tm1.1Rpbh,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Arl6ip5tm1.2Jwzh/Arl6ip5tm1.2Jwzh
Genetic Background: B6.129X1-Arl6ip5tm1.2Jwzh

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Col27a1tm1.1Rpbh/Col27a1tm1.1Rpbh,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Arl6ip5tm1Tnkk/Arl6ip5+
Genetic Background: either: B6.Cg-Arl6ip5tm1Tnkk or (involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Antxr2tm1.1Jkit/Antxr2tm1.1Jkit
Genetic Background: involves: 129 * C57BL/6

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arl6ip5tm1.2Jwzh/Arl6ip5tm1.2Jwzh
Genetic Background: B6.129X1-Arl6ip5tm1.2Jwzh

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Col27a1tm1.1Rpbh/Col27a1tm1.1Rpbh,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003186 abnormal redox activity "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col27a1tm1.1Rpbh/Col27a1tm1.1Rpbh,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Arl6ip5tm1.2Jwzh/Arl6ip5tm1.2Jwzh
Genetic Background: B6.129X1-Arl6ip5tm1.2Jwzh

 MP:0003453 abnormal keratinocyte physiology "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860]
Show

Allelic Composition: Arl6ip5tm1.2Jwzh/Arl6ip5tm1.2Jwzh
Genetic Background: B6.129X1-Arl6ip5tm1.2Jwzh

 MP:0003858 enhanced coordination "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col27a1tm1.1Rpbh/Col27a1tm1.1Rpbh,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arl6ip5tm1.2Jwzh/Arl6ip5tm1.2Jwzh
Genetic Background: B6.129X1-Arl6ip5tm1.2Jwzh

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col27a1tm1.1Rpbh/Col27a1tm1.1Rpbh,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr