ENSMUSG00000035236


Mus musculus

Features
Gene ID: ENSMUSG00000035236
  
Biological name :Scai
  
Synonyms : Protein SCAI / Q8C8N2 / Scai
  
Possible biological names infered from orthology : Q8N9R8 / suppressor of cancer cell invasion
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 39066214
Gene end: 39190734
  
Corresponding Affymetrix probe sets: 10482301 (MoGene1.0st)   1435266_at (Mouse Genome 430 2.0 Array)   1440846_at (Mouse Genome 430 2.0 Array)   1445081_at (Mouse Genome 430 2.0 Array)   1456357_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116359
Ensembl peptide - ENSMUSP00000145381
Ensembl peptide - ENSMUSP00000145133
Ensembl peptide - ENSMUSP00000144844
Ensembl peptide - ENSMUSP00000118536
Ensembl peptide - ENSMUSP00000037194
NCBI entrez gene - 320271     See in Manteia.
MGI - MGI:2443716
RefSeq - XM_011239115
RefSeq - NM_178778
RefSeq - XM_011239113
RefSeq Peptide - NP_848893
swissprot - B0R0E3
swissprot - D6RHQ0
swissprot - Q8C8N2
swissprot - A0A0N4SVJ6
swissprot - A0A0N4SUW0
Ensembl - ENSMUSG00000035236
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scaiENSDARG00000060865Danio rerio
 SCAIENSGALG00000001037Gallus gallus
 SCAIENSG00000173611Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR016607  Protein SCAI, metazoan/viridiplantae
 IPR022709  Protein SCAI


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0035024 negative regulation of Rho protein signal transduction IDA
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zfp36l3tm1Pjb/Y
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Zfp36l3tm1Pjb/Y
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: Zfp36l3tm1Pjb/Y
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Zfp36l3tm1Pjb/Y
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Zfp36l3tm1Pjb/Y
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0003992 increased mortality induced by ionizing radiation "greater sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Zfp36l3tm1Pjb/Y
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zfp36l3tm1Pjb/Y
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Zfp36l3tm1Pjb/Y
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
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Allelic Composition: Zfp36l3tm1Pjb/Y
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0011123 abnormal primary ovarian follicle number "abnormal numbers of the ovarian follicle prior to the appearance of an antrum, normally marked by developmental changes in the primary oocyte and follicular cells so that the latter form one or more layers of cuboidal or columnar cells; the follicle becomes surrounded by a sheath of stroma, the theca" [MGI:csmith]
Show

Allelic Composition: Zfp36l3tm1Pjb/Y
Genetic Background: involves: C57BL/6 * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015605 Srf / Q9JM73 / Serum response factor / P11831*  / reaction / complex
 ENSMUSG00000042292 Mkl1 / Q8K4J6 / MKL/myocardin-like protein 1 / Q969V6* / megakaryoblastic leukemia (translocation) 1*  / reaction / complex






 

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