ENSMUSG00000035596


Mus musculus

Features
Gene ID: ENSMUSG00000035596
  
Biological name :Mboat7
  
Synonyms : Lysophospholipid acyltransferase 7 / Mboat7 / Q8CHK3
  
Possible biological names infered from orthology : membrane bound O-acyltransferase domain containing 7 / Q96N66
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A1
Gene start: 3677789
Gene end: 3693523
  
Corresponding Affymetrix probe sets: 10559436 (MoGene1.0st)   1447846_x_at (Mouse Genome 430 2.0 Array)   1451066_at (Mouse Genome 430 2.0 Array)   1457997_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112710
Ensembl peptide - ENSMUSP00000146067
Ensembl peptide - ENSMUSP00000145801
Ensembl peptide - ENSMUSP00000145657
Ensembl peptide - ENSMUSP00000120521
Ensembl peptide - ENSMUSP00000116446
Ensembl peptide - ENSMUSP00000037107
NCBI entrez gene - 77582     See in Manteia.
MGI - MGI:1924832
RefSeq - XM_011250742
RefSeq - NM_029934
RefSeq - XM_006540432
RefSeq - XM_006540433
RefSeq Peptide - NP_084210
swissprot - D3YU33
swissprot - D6RHB6
swissprot - Q8CHK3
swissprot - A0A0U1RPP4
swissprot - A0A0U1RP26
swissprot - F6UP63
swissprot - A0A0U1RNQ0
Ensembl - ENSMUSG00000035596
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mboat7ENSDARG00000033436Danio rerio
 MBOAT7ENSG00000125505Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mboat1 / Q8BH98 / membrane bound O-acyltransferase domain containing 1 / Q6ZNC8*ENSMUSG0000003873223
Mboat2 / Q8R3I2 / Lysophospholipid acyltransferase 2 / Q6ZWT7* / membrane bound O-acyltransferase domain containing 2*ENSMUSG0000002064622
Lpcat3 / Q91V01 / Lysophospholipid acyltransferase 5 / Q6P1A2* / lysophosphatidylcholine acyltransferase 3*ENSMUSG0000000427017
Mboat4 / P0C7A3 / Ghrelin O-acyltransferase / Q96T53* / membrane bound O-acyltransferase domain containing 4*ENSMUSG0000007111315


Protein motifs (from Interpro)
Interpro ID Name
 IPR004299  Membrane bound O-acyl transferase, MBOAT


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process IEA
 biological_processGO:0008654 phospholipid biosynthetic process IEA
 biological_processGO:0021591 ventricular system development IMP
 biological_processGO:0021819 layer formation in cerebral cortex IMP
 biological_processGO:0046488 phosphatidylinositol metabolic process IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0071617 lysophospholipid acyltransferase activity IMP


Pathways (from Reactome)
Pathway description
Acyl chain remodelling of PI


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000440 domed skull 
Show

Allelic Composition: Mboat7tm1a(KOMP)Wtsi/Mboat7tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000784 forebrain hypoplasia "reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mboat7tm1Arai/Mboat7tm1Arai
Genetic Background: B6.129P2-Mboat7tm1Arai

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Mboat7tm1Arai/Mboat7tm1Arai
Genetic Background: B6.129P2-Mboat7tm1Arai

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Mboat7tm1Arai/Mboat7tm1Arai
Genetic Background: B6.129P2-Mboat7tm1Arai

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
Show

Allelic Composition: Celsr2tm1Lex/Celsr2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000827 dilated third ventricle "enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Celsr2tm1Lex/Celsr2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001157 small seminal gland "reduced size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Celsr2tm1Lex/Celsr2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Mboat7tm1Arai/Mboat7tm1Arai
Genetic Background: B6.129P2-Mboat7tm1Arai

Allelic Composition: Mboat7tm1a(KOMP)Wtsi/Mboat7tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Mboat7tm1a(KOMP)Wtsi/Mboat7tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
Show

Allelic Composition: Ctdnep1tm1Ryn/Ctdnep1+,Wnt3tm1Brd/Wnt3+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001492 piloerection "the involuntary bristling of hairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mboat7tm1a(KOMP)Wtsi/Mboat7tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Celsr2tm1Lex/Celsr2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Celsr2tm1Lex/Celsr2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Mboat7tm1Arai/Mboat7tm1Arai
Genetic Background: B6.129P2-Mboat7tm1Arai

Allelic Composition: Mboat7tm1a(KOMP)Wtsi/Mboat7tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mboat7tm1a(KOMP)Wtsi/Mboat7tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Mboat7tm1Arai/Mboat7tm1Arai
Genetic Background: B6.129P2-Mboat7tm1Arai

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mboat7tm1a(KOMP)Wtsi/Mboat7tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mboat7tm1Arai/Mboat7tm1Arai
Genetic Background: B6.129P2-Mboat7tm1Arai

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mboat7tm1Arai/Mboat7tm1Arai
Genetic Background: B6.129P2-Mboat7tm1Arai

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mboat7tm1Arai/Mboat7tm1Arai
Genetic Background: B6.129P2-Mboat7tm1Arai

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mboat7tm1Arai/Mboat7tm1Arai
Genetic Background: B6.129P2-Mboat7tm1Arai

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
Show

Allelic Composition: Mboat7tm1Arai/Mboat7tm1Arai
Genetic Background: B6.129P2-Mboat7tm1Arai

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mboat7tm1Arai/Mboat7tm1Arai
Genetic Background: B6.129P2-Mboat7tm1Arai

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mboat7tm1a(KOMP)Wtsi/Mboat7tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Mboat7tm1Arai/Mboat7tm1Arai
Genetic Background: B6.129P2-Mboat7tm1Arai

Allelic Composition: Mboat7tm1a(KOMP)Wtsi/Mboat7tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Mboat7tm1Arai/Mboat7tm1Arai
Genetic Background: B6.129P2-Mboat7tm1Arai

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Marveld2tm1b(EUCOMM)Wtsi/Marveld2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Marveld2tm1b(EUCOMM)Wtsi/H

 MP:0011495 abnormal head shape "any anomaly in the characteristic surface outline or contour of a head of an organism" [MGI:csmith]
Show

Allelic Composition: Celsr2tm1Lex/Celsr2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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