Manteia - Molecule gene

ENSMUSG00000004270

Mus musculus

Features

Gene ID:	ENSMUSG00000004270

Biological name :	Lpcat3

Synonyms :	Lpcat3 / Lysophospholipid acyltransferase 5 / Q91V01

Possible biological names infered from orthology :	lysophosphatidylcholine acyltransferase 3 / Q6P1A2

Species:	Mus musculus

Chr. number:	6
Strand:	1
Band:	F2
Gene start:	124663027
Gene end:	124704418

Corresponding Affymetrix probe sets:	10541695 (MoGene1.0st) 1423960_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000144738 Ensembl peptide - ENSMUSP00000004381 NCBI entrez gene - 14792 See in Manteia. MGI - MGI:1315211 RefSeq - NM_145130 RefSeq - XM_006505563 RefSeq Peptide - NP_660112 swissprot - A0A0N4SUM3 swissprot - Q91V01 Ensembl - ENSMUSG00000004270

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
lpcat3	ENSDARG00000075178	Danio rerio
LPCAT3	ENSGALG00000014570	Gallus gallus
LPCAT3	ENSG00000111684	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Mboat2 / Q8R3I2 / Lysophospholipid acyltransferase 2 / Q6ZWT7* / membrane bound O-acyltransferase domain containing 2*	ENSMUSG00000020646	22
Mboat1 / Q8BH98 / membrane bound O-acyltransferase domain containing 1 / Q6ZNC8*	ENSMUSG00000038732	21
Mboat7 / Q8CHK3 / Lysophospholipid acyltransferase 7 / Q96N66* / membrane bound O-acyltransferase domain containing 7*	ENSMUSG00000035596	17
Mboat4 / P0C7A3 / Ghrelin O-acyltransferase / Q96T53* / membrane bound O-acyltransferase domain containing 4*	ENSMUSG00000071113	15

Protein motifs (from Interpro)

Interpro ID	Name
IPR004299	Membrane bound O-acyl transferase, MBOAT

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006629	lipid metabolic process	IEA
biological_process	GO:0006644	phospholipid metabolic process	IEA
biological_process	GO:0008654	phospholipid biosynthetic process	IEA
biological_process	GO:0097006	regulation of plasma lipoprotein particle levels	IMP
cellular_component	GO:0005783	endoplasmic reticulum	IEA
cellular_component	GO:0005789	endoplasmic reticulum membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0016746	transferase activity, transferring acyl groups	IEA
molecular_function	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity	IEA

Pathways (from Reactome)

Pathway description

Acyl chain remodelling of PC

Acyl chain remodelling of PS

Acyl chain remodelling of PE

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000479	abnormal intestinal cell	"anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lpcat3^{tm1c(EUCOMM)Wtsi}/Lpcat3^{tm1c(EUCOMM)Wtsi},Tg(Vil1-cre)997Gum/0 Genetic Background: involves: C57BL/6 * C57BL/6N * SJL
MP:0000609	abnormal liver physiology	"aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: A/?,Tyr^c/Tyr^em12Ove Genetic Background: involves: C57BL/6 * FVB
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Cdh23^12J/Cdh23^v-2J Genetic Background: involves: C57BL/6J
MP:0001547	abnormal lipid level	"anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lpcat3^{tm1c(EUCOMM)Wtsi}/Lpcat3^{tm1c(EUCOMM)Wtsi},Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * C57BL/6N * SJL Allelic Composition: Lpcat3^{tm1c(EUCOMM)Wtsi}/Lpcat3^{tm1c(EUCOMM)Wtsi},Tg(Vil1-cre)997Gum/0 Genetic Background: involves: C57BL/6 * C57BL/6N * SJL
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lpcat3^{tm1c(EUCOMM)Wtsi}/Lpcat3^{tm1c(EUCOMM)Wtsi},Tg(Vil1-cre)997Gum/0 Genetic Background: involves: C57BL/6 * C57BL/6N * SJL
MP:0002118	abnormal lipid homeostasis	"anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: A/?,Tyr^c/Tyr^em12Ove Genetic Background: involves: C57BL/6 * FVB
MP:0002628	fatty liver	"an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Lpcat3^{tm1c(EUCOMM)Wtsi}/Lpcat3^{tm1c(EUCOMM)Wtsi},Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * C57BL/6N * SJL
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: A/?,Tyr^c/Tyr^em12Ove Genetic Background: involves: C57BL/6 * FVB Allelic Composition: Lpcat3^{tm1c(EUCOMM)Wtsi}/Lpcat3^{tm1c(EUCOMM)Wtsi},Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * C57BL/6N * SJL Allelic Composition: Lpcat3^{tm1c(EUCOMM)Wtsi}/Lpcat3^{tm1c(EUCOMM)Wtsi},Tg(Vil1-cre)997Gum/0 Genetic Background: involves: C57BL/6 * C57BL/6N * SJL
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Lpcat3^{tm1c(EUCOMM)Wtsi}/Lpcat3^{tm1c(EUCOMM)Wtsi},Tg(Vil1-cre)997Gum/0 Genetic Background: involves: C57BL/6 * C57BL/6N * SJL
MP:0003976	decreased circulating VLDL triglyceride level	"lower than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Lpcat3^{tm1c(EUCOMM)Wtsi}/Lpcat3^{tm1c(EUCOMM)Wtsi},Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * C57BL/6N * SJL
MP:0004777	abnormal phospholipid level	"anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lpcat3^{tm1c(EUCOMM)Wtsi}/Lpcat3^{tm1c(EUCOMM)Wtsi},Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * C57BL/6N * SJL
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: A/?,Tyr^c/Tyr^em12Ove Genetic Background: involves: C57BL/6 * FVB Allelic Composition: Lpcat3^{tm1c(EUCOMM)Wtsi}/Lpcat3^{tm1c(EUCOMM)Wtsi},Tg(Vil1-cre)997Gum/0 Genetic Background: involves: C57BL/6 * C57BL/6N * SJL
MP:0009355	increased liver triglyceride level	"higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lpcat3^{tm1c(EUCOMM)Wtsi}/Lpcat3^{tm1c(EUCOMM)Wtsi},Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * C57BL/6N * SJL
MP:0010027	increased liver cholesterol level	"greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lpcat3^{tm1c(EUCOMM)Wtsi}/Lpcat3^{tm1c(EUCOMM)Wtsi},Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * C57BL/6N * SJL
MP:0010332	abnormal circulating apolipoprotein level	"anomaly in the amount in the blood of a protein that is frequently a component of a lipoprotein complex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Lpcat3^{tm1c(EUCOMM)Wtsi}/Lpcat3^{tm1c(EUCOMM)Wtsi},Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * C57BL/6N * SJL
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: A/?,Tyr^c/Tyr^em12Ove Genetic Background: involves: C57BL/6 * FVB
MP:0013245	abnormal lipid metabolism	"any anomaly in the chemical reactions and pathways involving a lipid, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]	Show Allelic Composition: A/?,Tyr^c/Tyr^em12Ove Genetic Background: involves: C57BL/6 * FVB

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr