ENSMUSG00000035842


Mus musculus

Features
Gene ID: ENSMUSG00000035842
  
Biological name :Ddx11
  
Synonyms : Ddx11 / Mus musculus DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 (Ddx11), transcript variant 2, mRNA. / Q6AXC6
  
Possible biological names infered from orthology : DEAD/H-box helicase 11 / Q96FC9
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E1.1
Gene start: 66123520
Gene end: 66152174
  
Corresponding Affymetrix probe sets: 10446441 (MoGene1.0st)   1438447_at (Mouse Genome 430 2.0 Array)   1441062_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153436
Ensembl peptide - ENSMUSP00000153635
Ensembl peptide - ENSMUSP00000130440
Ensembl peptide - ENSMUSP00000152906
NCBI entrez gene - 320209     See in Manteia.
MGI - MGI:2443590
RefSeq - XM_006524411
RefSeq - NM_001003919
RefSeq - NM_001348292
RefSeq - XM_006524408
RefSeq - XM_006524409
RefSeq - XM_006524410
RefSeq Peptide - NP_001335221
RefSeq Peptide - NP_001003919
swissprot - A0A286YDY6
swissprot - A0A286YDJ5
swissprot - Q6AXC6
swissprot - A0A286YCB9
Ensembl - ENSMUSG00000035842
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddx11ENSDARG00000011072Danio rerio
 ENSGALG00000039636Gallus gallus
 DDX11ENSG00000013573Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Brip1 / Q5SXJ3 / Fanconi anemia group J protein homolog / Q9BX63* / BRCA1 interacting protein C-terminal helicase 1*ENSMUSG0000003432924
Rtel1 / Q0VGM9 / Regulator of telomere elongation helicase 1 / Q9NZ71* / RTEL1-TNFRSF6B* / RTEL1-TNFRSF6B readthrough (NMD candidate)*ENSMUSG0000003868524


Protein motifs (from Interpro)
Interpro ID Name
 IPR006554  Helicase-like, DEXD box c2 type
 IPR006555  ATP-dependent helicase, C-terminal
 IPR010614  DEAD2
 IPR013020  ATP-dependent helicase Rad3/Chl1-like
 IPR014013  Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR028331  Probable ATP-dependent RNA helicase DDX11/DDX12


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006139 nucleobase-containing compound metabolic process IEA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007062 sister chromatid cohesion IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0031297 replication fork processing IEA
 biological_processGO:0032079 positive regulation of endodeoxyribonuclease activity IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0035563 positive regulation of chromatin binding IEA
 biological_processGO:0044806 G-quadruplex DNA unwinding IEA
 biological_processGO:0045876 positive regulation of sister chromatid cohesion IEA
 biological_processGO:0072711 cellular response to hydroxyurea IEA
 biological_processGO:0072719 cellular response to cisplatin IEA
 biological_processGO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IEA
 biological_processGO:1904976 cellular response to bleomycin IEA
 biological_processGO:1990700 nucleolar chromatin organization IEA
 biological_processGO:2000781 positive regulation of double-strand break repair IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0000922 spindle pole ISO
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0031390 Ctf18 RFC-like complex IEA
 cellular_componentGO:0070062 extracellular exosome ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003688 DNA replication origin binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity ISS
 molecular_functionGO:0004386 helicase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008026 ATP-dependent helicase activity ISS
 molecular_functionGO:0008094 DNA-dependent ATPase activity IEA
 molecular_functionGO:0008186 RNA-dependent ATPase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
 molecular_functionGO:0045142 triplex DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA
 molecular_functionGO:0051880 G-quadruplex DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Ddx11cetus/Ddx11cetus
Genetic Background: either: C3Fe.B6-Ddx11cetus or (involves: C3HeB/FeJ * C57BL/6J * CAST/Ei)

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
Show

Allelic Composition: Ddx11cetus/Ddx11cetus
Genetic Background: either: C3Fe.B6-Ddx11cetus or (involves: C3HeB/FeJ * C57BL/6J * CAST/Ei)

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fcgrttm1Dcr/Fcgrttm1Dcr
Genetic Background: B6.129X1-Fcgrttm1Dcr/DcrJ

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ddx11cetus/Ddx11cetus
Genetic Background: either: C3Fe.B6-Ddx11cetus or (involves: C3HeB/FeJ * C57BL/6J * CAST/Ei)

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

Allelic Composition: Ddx11cetus/Ddx11cetus
Genetic Background: either: C3Fe.B6-Ddx11cetus or (involves: C3HeB/FeJ * C57BL/6J * CAST/Ei)

Allelic Composition: Ddx11cetus/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv * C3HeB/FeJ * C57BL/6J

 MP:0001715 placental labyrinth hypoplasia "reduction in cell number of the placental labyrinth, the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Ugdhlzme/Ugdhlzme
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

Allelic Composition: Ddx11cetus/Ddx11cetus
Genetic Background: either: C3Fe.B6-Ddx11cetus or (involves: C3HeB/FeJ * C57BL/6J * CAST/Ei)

Allelic Composition: Ddx11cetus/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv * C3HeB/FeJ * C57BL/6J

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clcn7tm1.1Lex/Clcn7tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

Allelic Composition: Ddx11cetus/Ddx11cetus
Genetic Background: either: C3Fe.B6-Ddx11cetus or (involves: C3HeB/FeJ * C57BL/6J * CAST/Ei)

Allelic Composition: Ddx11cetus/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv * C3HeB/FeJ * C57BL/6J

 MP:0003891 increased allantois apoptosis "increase in the number of cells of the allantois undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ddx11cetus/Ddx11cetus
Genetic Background: either: C3Fe.B6-Ddx11cetus or (involves: C3HeB/FeJ * C57BL/6J * CAST/Ei)

 MP:0004559 small allantois "reduced size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ddx11cetus/Ddx11cetus
Genetic Background: either: C3Fe.B6-Ddx11cetus or (involves: C3HeB/FeJ * C57BL/6J * CAST/Ei)

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

Allelic Composition: Ddx11cetus/Ddx11cetus
Genetic Background: either: C3Fe.B6-Ddx11cetus or (involves: C3HeB/FeJ * C57BL/6J * CAST/Ei)

Allelic Composition: Ddx11cetus/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv * C3HeB/FeJ * C57BL/6J

 MP:0008932 abnormal embryonic tissue physiology "any functional anomaly in any of the tissues of the embryo proper" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

Allelic Composition: Ddx11cetus/Ddx11cetus
Genetic Background: either: C3Fe.B6-Ddx11cetus or (involves: C3HeB/FeJ * C57BL/6J * CAST/Ei)

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ugdhlzme/Ugdhlzme
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

Allelic Composition: Ddx11cetus/Ddx11cetus
Genetic Background: either: C3Fe.B6-Ddx11cetus or (involves: C3HeB/FeJ * C57BL/6J * CAST/Ei)

 MP:0011199 abnormal amniotic cavity morphology "any structural anomaly of the closed space between the embryo and the amnion, containing the amniotic fluid; it is formed by the fusion of the parts of the anterior and posterior amniotic folds" [ISBN:0-12-402035-6]
Show

Allelic Composition: Ddx11cetus/Ddx11cetus
Genetic Background: either: C3Fe.B6-Ddx11cetus or (involves: C3HeB/FeJ * C57BL/6J * CAST/Ei)

 MP:0012113 decreased inner cell mass proliferation 
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

 MP:0012183 decreased paraxial mesoderm size "reduced size or deficiency of the mesoderm lying at either side of the midline embryonic notochord that, on segmentation, forms the paired somites" [MGI:anna]
Show

Allelic Composition: Ugdhlzme/Ugdhlzme
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Ddx11cetus/Ddx11cetus
Genetic Background: either: C3Fe.B6-Ddx11cetus or (involves: C3HeB/FeJ * C57BL/6J * CAST/Ei)

 MP:0012184 absent paraxial mesoderm "absence or loss of the mesoderm normally found at either side of the midline embryonic notochord that, on segmentation, forms the paired somites." [MGI:anna]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

Allelic Composition: Ddx11cetus/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv * C3HeB/FeJ * C57BL/6J

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

Allelic Composition: Ddx11cetus/Ddx11cetus
Genetic Background: either: C3Fe.B6-Ddx11cetus or (involves: C3HeB/FeJ * C57BL/6J * CAST/Ei)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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