ENSMUSG00000035873


Mus musculus

Features
Gene ID: ENSMUSG00000035873
  
Biological name :Pawr
  
Synonyms : Pawr / PRKC apoptosis WT1 regulator protein / Q925B0
  
Possible biological names infered from orthology : pro-apoptotic WT1 regulator / Q96IZ0
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D1
Gene start: 108332121
Gene end: 108414240
  
Corresponding Affymetrix probe sets: 10366266 (MoGene1.0st)   1426910_at (Mouse Genome 430 2.0 Array)   1445390_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000092951
Ensembl peptide - ENSMUSP00000151457
NCBI entrez gene - 114774     See in Manteia.
MGI - MGI:2149961
RefSeq - NM_054056
RefSeq Peptide - NP_473397
swissprot - Q925B0
Ensembl - ENSMUSG00000035873
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pawrENSDARG00000045486Danio rerio
 PAWRENSGALG00000010320Gallus gallus
 PAWRENSG00000177425Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026117  Prostate apoptosis response 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition NAS
 biological_processGO:0030889 negative regulation of B cell proliferation IMP
 biological_processGO:0042094 interleukin-2 biosynthetic process IMP
 biological_processGO:0042130 negative regulation of T cell proliferation IMP
 biological_processGO:0042986 positive regulation of amyloid precursor protein biosynthetic process IDA
 biological_processGO:0043065 positive regulation of apoptotic process IBA
 biological_processGO:0048147 negative regulation of fibroblast proliferation IMP
 biological_processGO:0050860 negative regulation of T cell receptor signaling pathway IMP
 biological_processGO:0097190 apoptotic signaling pathway IGI
 biological_processGO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death IMP
 biological_processGO:2000774 positive regulation of cellular senescence IMP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005884 actin filament IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0043522 leucine zipper domain binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apctm2Tno/Apc+
Genetic Background: Not Specified

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Apctm2Tno/Apc+
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Afdntm1Ytk/Afdntm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Pawrtm1Yshi/Pawrtm1Yshi,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: FVB/N

Allelic Composition: Pawrtm1Rang/Pawrtm1Rang
Genetic Background: C57BL/6NTac-Pawrtm1Rang

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
Show

Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apctm2Tno/Apc+
Genetic Background: Not Specified

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apctm2Tno/Apc+
Genetic Background: Not Specified

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apctm2Tno/Apc+
Genetic Background: Not Specified

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apctm2Tno/Apc+
Genetic Background: Not Specified

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apctm2Tno/Apc+
Genetic Background: Not Specified

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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