ENSMUSG00000035914


Mus musculus

Features
Gene ID: ENSMUSG00000035914
  
Biological name :Cd276
  
Synonyms : Cd276 / CD276 antigen / Q8VE98
  
Possible biological names infered from orthology : CD276 molecule / Q5ZPR3
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: B
Gene start: 58524298
Gene end: 58555437
  
Corresponding Affymetrix probe sets: 10594092 (MoGene1.0st)   1417599_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000042681
Ensembl peptide - ENSMUSP00000151025
Ensembl peptide - ENSMUSP00000150714
Ensembl peptide - ENSMUSP00000129418
NCBI entrez gene - 102657     See in Manteia.
MGI - MGI:2183926
RefSeq - NM_133983
RefSeq Peptide - NP_598744
swissprot - A0A1L1SV51
swissprot - A0A1L1SUD4
swissprot - A6MDC5
swissprot - Q8VE98
Ensembl - ENSMUSG00000035914
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cd276ENSDARG00000003061Danio rerio
 CD276ENSGALG00000001729Gallus gallus
 CD276ENSG00000103855Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Icosl / Q9JHJ8 / icos ligand / ICOSLG* / O75144* / FP565260.3* / inducible T cell costimulator ligand*ENSMUSG0000000073225
Vtcn1 / Q7TSP5 / V-set domain containing T cell activation inhibitor 1 / Q7Z7D3*ENSMUSG0000005107620


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030501 positive regulation of bone mineralization IMP
 biological_processGO:0042102 positive regulation of T cell proliferation ISO
 biological_processGO:0042110 T cell activation ISO
 biological_processGO:0042130 negative regulation of T cell proliferation IMP
 biological_processGO:0045077 negative regulation of interferon-gamma biosynthetic process IMP
 biological_processGO:0045078 positive regulation of interferon-gamma biosynthetic process ISO
 biological_processGO:0045085 negative regulation of interleukin-2 biosynthetic process IDA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IMP
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 biological_processGO:0050776 regulation of immune response IMP
 biological_processGO:1900042 positive regulation of interleukin-2 secretion IMP
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IMP
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

Allelic Composition: Cd276tm1Mak/Cd276tm1Mak
Genetic Background: C.129P2-Cd276tm1Mak

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adgrv1tm1Msat/Adgrv1tm1Msat
Genetic Background: B6.129P2-Adgrv1tm1Msat

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
Show

Allelic Composition: Cd276tm1Lpc/Cd276tm1Lpc
Genetic Background: D1J.129-Cd276tm1Lpc

 MP:0004771 increased anti-single stranded DNA antibody level "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd276tm1Lpc/Cd276tm1Lpc
Genetic Background: B6.129-Cd276tm1Lpc

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

Allelic Composition: Cd276tm1Mak/Cd276tm1Mak
Genetic Background: C.129P2-Cd276tm1Mak

Allelic Composition: Cd276tm1Lpc/Cd276tm1Lpc
Genetic Background: B6.129-Cd276tm1Lpc

Allelic Composition: Cd276tm1Lpc/Cd276tm1Lpc
Genetic Background: D1J.129-Cd276tm1Lpc

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd276tm1Lpc/Cd276tm1Lpc
Genetic Background: B6.129-Cd276tm1Lpc

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd276tm1Lpc/Cd276tm1Lpc
Genetic Background: B6.129-Cd276tm1Lpc

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
Show

Allelic Composition: Adgrv1tm1Msat/Adgrv1tm1Msat
Genetic Background: B6.129P2-Adgrv1tm1Msat

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Cd276tm1Mak/Cd276tm1Mak
Genetic Background: C.129P2-Cd276tm1Mak

 MP:0010222 abnormal T-helper 17 cell physiology "any functional anomaly of a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
Show

Allelic Composition: Cd276tm1Lpc/Cd276tm1Lpc
Genetic Background: D1J.129-Cd276tm1Lpc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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