ENSMUSG00000051076


Mus musculus

Features
Gene ID: ENSMUSG00000051076
  
Biological name :Vtcn1
  
Synonyms : Q7TSP5 / V-set domain containing T cell activation inhibitor 1 / Vtcn1
  
Possible biological names infered from orthology : Q7Z7D3
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.2
Gene start: 100825459
Gene end: 100896922
  
Corresponding Affymetrix probe sets: 10494761 (MoGene1.0st)   1458070_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057721
NCBI entrez gene - 242122     See in Manteia.
MGI - MGI:3039619
RefSeq - NM_178594
RefSeq Peptide - NP_848709
swissprot - Q7TSP5
Ensembl - ENSMUSG00000051076
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vtcn1ENSDARG00000078643Danio rerio
 ENSGALG00000014820Gallus gallus
 VTCN1ENSG00000134258Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cd276 / Q8VE98 / CD276 antigen / Q5ZPR3* / CD276 molecule*ENSMUSG0000003591423
Icosl / Q9JHJ8 / icos ligand / ICOSLG* / O75144* / FP565260.3* / inducible T cell costimulator ligand*ENSMUSG0000000073216


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001562 response to protozoan IMP
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IMP
 biological_processGO:0042130 negative regulation of T cell proliferation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0050868 negative regulation of T cell activation IEA
 biological_processGO:0072602 interleukin-4 secretion IMP
 biological_processGO:0072643 interferon-gamma secretion IMP
 biological_processGO:1900042 positive regulation of interleukin-2 secretion IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IGI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: C2cd3hty/C2cd3Gt(AG0177)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C3H/He * C57BL/6

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Vtcn1tm1Lpc/Vtcn1tm1Lpc
Genetic Background: involves: 129S/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: C2cd3hty/C2cd3Gt(AG0177)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C3H/He * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: C2cd3hty/C2cd3Gt(AG0177)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C3H/He * C57BL/6

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Vtcn1tm1Lpc/Vtcn1tm1Lpc
Genetic Background: involves: 129S/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0002415 abnormal neutrophil morphology/development "anomalous structure, differentiation, or number of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Vtcn1tm1Lpc/Vtcn1tm1Lpc
Genetic Background: involves: 129S/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arih2tm1Mak/Arih2tm1Mak
Genetic Background: B6.129P2-Arih2tm1Mak

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arih2tm1Mak/Arih2tm1Mak
Genetic Background: B6.129P2-Arih2tm1Mak

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Vtcn1tm1Lpc/Vtcn1tm1Lpc
Genetic Background: involves: 129S/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Arih2tm1Mak/Arih2tm1Mak
Genetic Background: B6.129P2-Arih2tm1Mak

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arih2tm1Mak/Arih2tm1Mak
Genetic Background: B6.129P2-Arih2tm1Mak

 MP:0008086 increased T-helper 1 cell number "greater number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149]
Show

Allelic Composition: Arih2tm1Mak/Arih2tm1Mak
Genetic Background: B6.129P2-Arih2tm1Mak

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Arih2tm1Mak/Arih2tm1Mak
Genetic Background: B6.129P2-Arih2tm1Mak

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arih2tm1Mak/Arih2tm1Mak
Genetic Background: B6.129P2-Arih2tm1Mak

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: C2cd3hty/C2cd3Gt(AG0177)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C3H/He * C57BL/6

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Vtcn1tm1Lpc/Vtcn1tm1Lpc
Genetic Background: involves: 129S/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0010219 increased T-helper 17 cell number "increased number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
Show

Allelic Composition: Arih2tm1Mak/Arih2tm1Mak
Genetic Background: B6.129P2-Arih2tm1Mak

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr