ENSMUSG00000035958


Mus musculus

Features
Gene ID: ENSMUSG00000035958
  
Biological name :Tdp2
  
Synonyms : Q9JJX7 / Tdp2 / tyrosyl-DNA phosphodiesterase 2
  
Possible biological names infered from orthology : O95551
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A3.1
Gene start: 24831679
Gene end: 24842153
  
Corresponding Affymetrix probe sets: 10404187 (MoGene1.0st)   1448706_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153301
Ensembl peptide - ENSMUSP00000153306
Ensembl peptide - ENSMUSP00000035660
NCBI entrez gene - 56196     See in Manteia.
MGI - MGI:1860486
RefSeq - NM_019551
RefSeq Peptide - NP_062424
swissprot - A0A286YDM0
swissprot - Q9JJX7
Ensembl - ENSMUSG00000035958
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tdp2aENSDARG00000069941Danio rerio
 tdp2bENSDARG00000035954Danio rerio
 TDP2ENSGALG00000013637Gallus gallus
 TDP2ENSG00000111802Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016235 aggresome IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0016605 PML body ISS
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity ISA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity ISA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030145 manganese ion binding IEA
 molecular_functionGO:0036317 tyrosyl-RNA phosphodiesterase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070260 5"-tyrosyl-DNA phosphodiesterase activity IEA


Pathways (from Reactome)
Pathway description
Nonhomologous End-Joining (NHEJ)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trim21tm1Mwah/Trim21+
Genetic Background: C57BL/6-Trim21tm1Mwah

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0003643 spleen atrophy "wasting of the spleen resulting in reduced size" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0005022 abnormal immature B cell "anomalous structure, development, or number of the cells of the B lymphocyte lineage that have undergone VDJ rearragnement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0011176 abnormal erythroblast morphology "any structural anomaly of the nucleated precursor of erythrocytes" [ISBN:0-683-40008-8]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0014078 small intestinal villus atrophy "erosion or abnormal flattening of the surface secondary to the shortening and blunting of the small intestinal villi; villus atrophy is a non-specific reaction of the intestinal mucosa to a variety of injuries; the pathogenesis is either associated with a hyper-regenerative increase in crypt cell mitoses leading to crypt elongation or it results from hyporegeneration, that is, reduced mitotic rate with shortened crypts" [MGI:Anna, PMID:16679353]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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