Manteia - Molecule gene

ENSMUSG00000036151

Mus musculus

Features

Gene ID:	ENSMUSG00000036151

Biological name :	Tm6sf2

Synonyms :	Tm6sf2 / transmembrane 6 superfamily member 2

Possible biological names infered from orthology :	Q9BZW4

Species:	Mus musculus

Chr. number:	8
Strand:	1
Band:	B3.3
Gene start:	70072924
Gene end:	70080066

Corresponding Affymetrix probe sets:	10572271 (MoGene1.0st) 1425079_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000046114 Ensembl peptide - ENSMUSP00000105788 NCBI entrez gene - 107770 See in Manteia. MGI - MGI:1933210 RefSeq - NM_001293795 RefSeq - NM_181540 RefSeq Peptide - NP_001280724 RefSeq Peptide - NP_853518 swissprot - E9QM19 swissprot - A0A0R4J0J9 Ensembl - ENSMUSG00000036151

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
tm6sf2	ENSDARG00000029057	Danio rerio
zgc:85843	ENSDARG00000105208	Danio rerio
TM6SF2	ENSGALG00000029015	Gallus gallus
Q9BZW4	ENSG00000213996	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
P58749 / Tm6sf1 / transmembrane 6 superfamily member 1 / Q9BZW5*	ENSMUSG00000038623	47

Protein motifs (from Interpro)

Interpro ID	Name
IPR033118	EXPERA domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0019216	regulation of lipid metabolic process	IEA
cellular_component	GO:0005789	endoplasmic reticulum membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000183	decreased circulating LDL cholesterol level	"less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae Allelic Composition: Tm6sf2^em1Yech/Tm6sf2^em1Yech Genetic Background: C57BL/6-Tm6sf2^em1Yech
MP:0000186	decreased circulating HDL cholesterol level	"lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae Allelic Composition: Tm6sf2^em1Yech/Tm6sf2^em1Yech Genetic Background: C57BL/6-Tm6sf2^em1Yech
MP:0000479	abnormal intestinal cell	"anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae
MP:0001552	increased circulating triglyceride level	"higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]	Show Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae Allelic Composition: Tm6sf2^em1Yech/Tm6sf2^em1Yech Genetic Background: C57BL/6-Tm6sf2^em1Yech
MP:0002628	fatty liver	"an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae
MP:0002647	decreased cholesterol absorption	"reduced ability of the body to take in these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae
MP:0002941	increased circulating alanine transaminase level	"increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae
MP:0003976	decreased circulating VLDL triglyceride level	"lower than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae Allelic Composition: Tm6sf2^em1Yech/Tm6sf2^em1Yech Genetic Background: C57BL/6-Tm6sf2^em1Yech
MP:0005278	abnormal cholesterol homeostasis	"anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]	Show Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae Allelic Composition: Tm6sf2^{tm1a(KOMP)Wtsi}/Tm6sf2⁺ Genetic Background: C57BL/6N-Tm6sf2^{tm1a(KOMP)Wtsi} Allelic Composition: Tm6sf2^em1Yech/Tm6sf2^em1Yech Genetic Background: C57BL/6-Tm6sf2^em1Yech
MP:0005317	increased triglyceride level	"higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae
MP:0005342	abnormal lipid absorption	"anomalous ability of the body to take in fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]	Show Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae
MP:0009355	increased liver triglyceride level	"higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae Allelic Composition: Tm6sf2^{tm1a(KOMP)Wtsi}/Tm6sf2⁺ Genetic Background: C57BL/6N-Tm6sf2^{tm1a(KOMP)Wtsi}
MP:0010332	abnormal circulating apolipoprotein level	"anomaly in the amount in the blood of a protein that is frequently a component of a lipoprotein complex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr