ENSMUSG00000036155


Mus musculus

Features
Gene ID: ENSMUSG00000036155
  
Biological name :Mgat5
  
Synonyms : Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A / Mgat5 / Q8R4G6
  
Possible biological names infered from orthology : mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase / Q09328
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E3
Gene start: 127205015
Gene end: 127488336
  
Corresponding Affymetrix probe sets: 10349404 (MoGene1.0st)   1425744_a_at (Mouse Genome 430 2.0 Array)   1428643_at (Mouse Genome 430 2.0 Array)   1428644_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038359
Ensembl peptide - ENSMUSP00000129166
NCBI entrez gene - 107895     See in Manteia.
MGI - MGI:894701
RefSeq - XM_006529057
RefSeq - NM_145128
RefSeq - XM_006529055
RefSeq - XM_006529056
RefSeq Peptide - NP_660110
swissprot - Q059T5
swissprot - Q8R4G6
Ensembl - ENSMUSG00000036155
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mgat5ENSDARG00000071506Danio rerio
 MGAT5ENSGALG00000012187Gallus gallus
 MGAT5ENSG00000152127Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mgat5b / Q765H6 / Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B / Q3V5L5* / mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B*ENSMUSG0000004385737


Protein motifs (from Interpro)
Interpro ID Name
 IPR026116  Glycosyltransferase family 18
 IPR027833  Domain of unknown function DUF4525


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006487 protein N-linked glycosylation IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008375 acetylglucosaminyltransferase activity IMP
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IDA
 molecular_functionGO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity IMP


Pathways (from Reactome)
Pathway description
N-Glycan antennae elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001273 decreased metastatic potential 
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

Allelic Composition: Mgat5tm1Jwd/Mgat5tm1Jwd,Mgat5btm1.1Itl/Mgat5btm1.1Itl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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