ENSMUSG00000043857


Mus musculus

Features
Gene ID: ENSMUSG00000043857
  
Biological name :Mgat5b
  
Synonyms : Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B / Mgat5b / Q765H6
  
Possible biological names infered from orthology : mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B / Q3V5L5
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E2
Gene start: 116918863
Gene end: 116986948
  
Corresponding Affymetrix probe sets: 10382866 (MoGene1.0st)   1434531_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099316
Ensembl peptide - ENSMUSP00000122276
NCBI entrez gene - 268510     See in Manteia.
MGI - MGI:3606200
RefSeq - NM_172948
RefSeq - XM_006533417
RefSeq Peptide - NP_766536
swissprot - F7BPB5
swissprot - Q765H6
Ensembl - ENSMUSG00000043857
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MGAT5BENSDARG00000115505Danio rerio
 MGAT5BENSGALG00000001740Gallus gallus
 MGAT5BENSG00000167889Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mgat5 / Q8R4G6 / Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A / Q09328* / mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase*ENSMUSG0000003615535


Protein motifs (from Interpro)
Interpro ID Name
 IPR026116  Glycosyltransferase family 18


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006487 protein N-linked glycosylation IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Notch1tm6.1Rko/Notch1tm6.1Rko,Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N

Allelic Composition: Mgat5tm1Jwd/Mgat5tm1Jwd,Mgat5btm1.1Itl/Mgat5btm1.1Itl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Notch1tm6.1Rko/Notch1tm6.1Rko,Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Notch1tm6.1Rko/Notch1tm6.1Rko,Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Notch1tm6.1Rko/Notch1tm6.1Rko,Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0010160 increased oligodendrocyte number "greater number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MESH:A08.637.600, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Notch1tm6.1Rko/Notch1tm6.1Rko,Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0020155 enhanced humoral immune response "enhanced response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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