| MP:0000062 | increased bone density | "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295] |
Show
Allelic Composition: Pdcd1tm1Hon/Pdcd1tm1Hon,Vsirtm1Lex/Vsirtm1Lex,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
Allelic Composition: Sostdc1tm2Snd/Sostdc1tm2Snd
Genetic Background: involves: 129S/SvEv
|
| MP:0000088 | short mandible | "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Trp53tm4Xu/Trp53tm4Xu
Genetic Background: Not Specified
|
| MP:0001092 | abnormal trigeminal ganglion morphology | "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038] |
Show
Allelic Composition: Gria1tm5Rlh/Gria1tm5Rlh
Genetic Background: involves: 129 * C57BL/6
|
| MP:0001661 | extended life span | "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec
Genetic Background: 129-Col4a3tm1Dec/J
|
| MP:0002100 | abnormal tooth morphology | "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Atf4tm1Kry/Atf4tm1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: C57BL/6J * FVB
|
| MP:0002743 | glomerulonephritis | "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec,Sostdc1tm1Myan/Sostdc1tm1Myan
Genetic Background: involves: 129X1/SvJ
|
| MP:0002871 | albuminuria | "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec,Sostdc1tm1Myan/Sostdc1tm1Myan
Genetic Background: involves: 129X1/SvJ
|
| MP:0002896 | abnormal bone mineralization | "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Pdcd1tm1Hon/Pdcd1tm1Hon,Vsirtm1Lex/Vsirtm1Lex,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
Allelic Composition: Sostdc1tm2Snd/Sostdc1tm2Snd
Genetic Background: involves: 129S/SvEv
|
| MP:0003215 | renal interstitial fibrosis | "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec,Sostdc1tm1Myan/Sostdc1tm1Myan
Genetic Background: involves: 129X1/SvJ
|
| MP:0003755 | abnormal palate | "anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request] |
Show
Allelic Composition: Trp53tm4Xu/Trp53tm4Xu
Genetic Background: Not Specified
|
| MP:0003756 | abnormal hard palate | "abnormality in the anterior part of the palate that is supported by and includes the palatal extensions of the maxillary and palatine bones " [ncbi:Matthew Mailman, NCBI request] |
Show
Allelic Composition: Trp53tm4Xu/Trp53tm4Xu
Genetic Background: Not Specified
|
| MP:0003932 | abnormal molar crown morphology | "defects in the upper part of the molar, which is normally covered with enamel " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Cdh23v-2J/Cdh23+,Myo7a4626SB/Myo7a+
Genetic Background: mixed
|
| MP:0004033 | supernumerary teeth | "occurrence of more than the usual number of teeth" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Snrpntm2Cbr/Snrpn+
Genetic Background: either: B6.Cg-Snrpntm2Cbr or (involves: 129S1/Sv * C57BL/6J * DBA/2J)
|
| MP:0004985 | decreased osteoclast cell number | "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Pdcd1tm1Hon/Pdcd1tm1Hon,Vsirtm1Lex/Vsirtm1Lex,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
|
| MP:0004988 | increased osteoblast cell number | "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Pdcd1tm1Hon/Pdcd1tm1Hon,Vsirtm1Lex/Vsirtm1Lex,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
|
| MP:0005006 | abnormal osteoblast function | "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Pdcd1tm1Hon/Pdcd1tm1Hon,Vsirtm1Lex/Vsirtm1Lex,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
|
| MP:0005264 | glomerulosclerosis | "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec,Sostdc1tm1Myan/Sostdc1tm1Myan
Genetic Background: involves: 129X1/SvJ
|
| MP:0005553 | increased circulating creatinine level | "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
Show
Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec,Sostdc1tm1Myan/Sostdc1tm1Myan
Genetic Background: involves: 129X1/SvJ
|
| MP:0005565 | increased blood urea nitrogen level | "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec,Sostdc1tm1Myan/Sostdc1tm1Myan
Genetic Background: involves: 129X1/SvJ
|
| MP:0005605 | increased bone mass | "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Pdcd1tm1Hon/Pdcd1tm1Hon,Vsirtm1Lex/Vsirtm1Lex,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
|
| MP:0006264 | decreased systolic blood pressure | "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887] |
Show
Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec,Sostdc1tm1Myan/Sostdc1tm1Myan
Genetic Background: involves: 129X1/SvJ
|
| MP:0006369 | supernumerary incisors | "more than a pair, top and/or bottom, of the long pointed teeth that are the most anterior and prominent in the jaw" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Trp53tm4Xu/Trp53tm4Xu
Genetic Background: Not Specified
Allelic Composition: Sostdc1shk/Sostdc1shk
Genetic Background: involves: C57BL/6J * CAST/EiJ * NOD
|
| MP:0008271 | abnormal bone ossification | "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503] |
Show
Allelic Composition: Pdcd1tm1Hon/Pdcd1tm1Hon,Vsirtm1Lex/Vsirtm1Lex,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
|
| MP:0008525 | decreased skull height | "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Trp53tm4Xu/Trp53tm4Xu
Genetic Background: Not Specified
|
| MP:0008526 | decreased skull width | "having a decreased side-to-side distance of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Trp53tm4Xu/Trp53tm4Xu
Genetic Background: Not Specified
|
| MP:0008874 | decreased sensitivity to xenobiotics | "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Snrpntm2Cbr/Snrpn+
Genetic Background: either: B6.Cg-Snrpntm2Cbr or (involves: 129S1/Sv * C57BL/6J * DBA/2J)
|
| MP:0009652 | abnormal palatal rugae | "any structural anomaly in the transversal ridges that develop on the secondary (hard) palate" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Trp53tm4Xu/Trp53tm4Xu
Genetic Background: Not Specified
|
| MP:0009767 | decreased sensitivity to xenobiotic induced morbidity/mortality | "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Snrpntm2Cbr/Snrpn+
Genetic Background: either: B6.Cg-Snrpntm2Cbr or (involves: 129S1/Sv * C57BL/6J * DBA/2J)
|
| MP:0010123 | increased bone mineral content | "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Pdcd1tm1Hon/Pdcd1tm1Hon,Vsirtm1Lex/Vsirtm1Lex,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
|
| MP:0010773 | supernumerary molars | "increased number of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Cdh23v-2J/Cdh23+,Myo7a4626SB/Myo7a+
Genetic Background: mixed
|
| MP:0010864 | abnormal enamel knot morphology | "any structural anomaly of a transient cluster of cells in the central part of the dental epithelium facing the dental mesenchyme, which acts as an organizing center, providing positional information for tooth morphogenesis and regulating the growth of tooth cusps" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8808404] |
Show
Allelic Composition: Cdh23v-2J/Cdh23+,Myo7a4626SB/Myo7a+
Genetic Background: mixed
|
| MP:0010878 | increased trabecular bone volume | "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Pdcd1tm1Hon/Pdcd1tm1Hon,Vsirtm1Lex/Vsirtm1Lex,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
|
| MP:0011088 | partial neonatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
Show
Allelic Composition: Gria1tm5Rlh/Gria1tm5Rlh
Genetic Background: involves: 129 * C57BL/6
|
| MP:0011110 | partial preweaning lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
Show
Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1l+
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi
Allelic Composition: Sostdc1tm2Snd/Sostdc1tm2Snd
Genetic Background: involves: 129S/SvEv
|
| MP:0011346 | renal tubule atrophy | "acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna] |
Show
Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec,Sostdc1tm1Myan/Sostdc1tm1Myan
Genetic Background: involves: 129X1/SvJ
|
| MP:0011372 | decreased renal tubule apoptosis | "decrease in the number of renal tubule cells undergoing programmed cell death" [MGI:anna] |
Show
Allelic Composition: Snrpntm2Cbr/Snrpn+
Genetic Background: either: B6.Cg-Snrpntm2Cbr or (involves: 129S1/Sv * C57BL/6J * DBA/2J)
|
| MP:0011402 | renal cast | "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna] |
Show
Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec,Sostdc1tm1Myan/Sostdc1tm1Myan
Genetic Background: involves: 129X1/SvJ
|
| MP:0014101 | decreased chondrocyte proliferation | "decreased amount of multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population" [GO:0035988] |
Show
Allelic Composition: Pdcd1tm1Hon/Pdcd1tm1Hon,Vsirtm1Lex/Vsirtm1Lex,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
|
| MP:0030438 | increased osteoblast proliferation | "increase in the expansion rate of osteoblasts by cell division; osteoblasts are skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [MGI:anna] |
Show
Allelic Composition: Pdcd1tm1Hon/Pdcd1tm1Hon,Vsirtm1Lex/Vsirtm1Lex,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
|
| MP:0030457 | abnormal molar cusp morphology | "any structural anomaly of an elevation or mound on the crown of a molar tooth making up a part of the occlusal (masticatory) surface" [https://medical-dictionary.thefreedictionary.com/cusp+of+tooth, MGI:anna] |
Show
Allelic Composition: Cdh23v-2J/Cdh23+,Myo7a4626SB/Myo7a+
Genetic Background: mixed
|
| MP:0030473 | fused molars | "union of two adjacent molar teeth in the maxilla and/or mandible" [MGI:anna] |
Show
Allelic Composition: Snrpntm2Cbr/Snrpn+
Genetic Background: either: B6.Cg-Snrpntm2Cbr or (involves: 129S1/Sv * C57BL/6J * DBA/2J)
Allelic Composition: Sostdc1tm1Nit/Sostdc1tm1Nit
Genetic Background: involves: 129S1/Sv * C57BL/6
|
