ENSMUSG00000036256


Mus musculus

Features
Gene ID: ENSMUSG00000036256
  
Biological name :Igfbp7
  
Synonyms : Igfbp7 / insulin like growth factor binding protein 7
  
Possible biological names infered from orthology : Q16270
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: C3.3
Gene start: 77349240
Gene end: 77408041
  
Corresponding Affymetrix probe sets: 10530841 (MoGene1.0st)   1423584_at (Mouse Genome 430 2.0 Array)   1423585_at (Mouse Genome 430 2.0 Array)   1437804_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128318
Ensembl peptide - ENSMUSP00000045057
NCBI entrez gene - 29817     See in Manteia.
MGI - MGI:1352480
RefSeq - NM_001159518
RefSeq - NM_008048
RefSeq Peptide - NP_001152990
RefSeq Peptide - NP_032074
swissprot - F8WH23
swissprot - E9Q5D9
Ensembl - ENSMUSG00000036256
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 igfbp7ENSDARG00000104138Danio rerio
 ENSGALG00000037332Gallus gallus
 IGFBP7ENSG00000163453Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q80W15 / Igfbpl1 / Insulin-like growth factor-binding protein-like 1 / Q8WX77*ENSMUSG0000003555133
Q8BJ66 / Kazald1 / Kazal-type serine protease inhibitor domain-containing protein 1 / Q96I82* / Kazal type serine peptidase inhibitor domain 1*ENSMUSG0000002521332


Protein motifs (from Interpro)
Interpro ID Name
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR002350  Kazal domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011390  Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25
 IPR013783  Immunoglobulin-like fold
 IPR036058  Kazal domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0050810 regulation of steroid biosynthetic process IEA
 biological_processGO:0051414 response to cortisol IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005520 insulin-like growth factor binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Igfbp7tm1.1Dds/Igfbp7+
Genetic Background: involves: CD-1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
Show

Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004047 abnormal milk composition "anomaly in the protein or lipid content of milk" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0006271 abnormal involution of the mammary gland "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0009506 abnormal mammary gland alveolus morphology "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0010174 decreased mammary gland epithelium proliferation "decrease in the expansion rate of the cells of the mammary gland epithelium by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0012075 impaired mammary gland growth during pregnancy "defect in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation in preparation for lactation" [MGI:llw2]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0013782 abnormal mammary duct terminal end bud morphology "any structural anomaly of the unique club-shaped epithelial structure that develops at the tip of the mammary duct at the onset of puberty (approximately 3 weeks of age in mouse) under the action of circulating hormones; terminal end buds (TEBs) consist of an outer layer of undifferentiated myoepithelial progenitor cells (cap cells), and a multilayered inner core of luminal epithelial cells (body) fated to form the walls of the ductal lumen; both layers have high rates of mitosis, consistent with a motile organ dedicated to ductal morphogenesis; TEBs proliferate, ramify, and actively invade the fad pad to allow the formation of a complex branching structure; this process of branching morphogenesis concludes at about 10-12 weeks of age in mouse, when TEBs have traversed the length of the fat pad and a fully developed ductal tree has formed" [MGI:Anna, PMID:16280048, PMID:16916375, PMID:18296651]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Igfbp7tm1.1Dds/Igfbp7+
Genetic Background: involves: CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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