ENSMUSG00000036257


Mus musculus

Features
Gene ID: ENSMUSG00000036257
  
Biological name :Pnpla8
  
Synonyms : Calcium-independent phospholipase A2-gamma / Pnpla8 / Q8K1N1
  
Possible biological names infered from orthology : patatin like phospholipase domain containing 8 / Q9NP80
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: B2
Gene start: 44221370
Gene end: 44322532
  
Corresponding Affymetrix probe sets: 10395538 (MoGene1.0st)   1417768_at (Mouse Genome 430 2.0 Array)   1442416_at (Mouse Genome 430 2.0 Array)   1444626_at (Mouse Genome 430 2.0 Array)   1457355_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116922
Ensembl peptide - ENSMUSP00000151660
Ensembl peptide - ENSMUSP00000151351
Ensembl peptide - ENSMUSP00000122560
Ensembl peptide - ENSMUSP00000120877
Ensembl peptide - ENSMUSP00000117126
Ensembl peptide - ENSMUSP00000043286
NCBI entrez gene - 67452     See in Manteia.
MGI - MGI:1914702
RefSeq - NM_026164
RefSeq - XM_006516174
RefSeq Peptide - NP_080440
swissprot - A0A1W2P6P7
swissprot - E9QAC9
swissprot - Q8K1N1
swissprot - F7B2N8
swissprot - E9PXB0
swissprot - D3Z5W9
swissprot - A0A1W2P7I1
Ensembl - ENSMUSG00000036257
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pnpla8ENSDARG00000078745Danio rerio
 PNPLA8ENSGALG00000009505Gallus gallus
 PNPLA8ENSG00000135241Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P97819 / Pla2g6 / phospholipase A2, group VI / O60733*ENSMUSG0000004263217


Protein motifs (from Interpro)
Interpro ID Name
 IPR002641  Patatin-like phospholipase domain
 IPR016035  Acyl transferase/acyl hydrolase/lysophospholipase
 IPR036438  Insulin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008219 cell death IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0019369 arachidonic acid metabolic process IEA
 biological_processGO:0034638 phosphatidylcholine catabolic process IEA
 biological_processGO:0043651 linoleic acid metabolic process IEA
 biological_processGO:0046338 phosphatidylethanolamine catabolic process IEA
 biological_processGO:0050482 arachidonic acid secretion IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005778 peroxisomal membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004622 lysophospholipase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0047499 calcium-independent phospholipase A2 activity IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodelling of PC
Acyl chain remodelling of PE


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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