ENSMUSG00000036570


Mus musculus

Features
Gene ID: ENSMUSG00000036570
  
Biological name :Fxyd1
  
Synonyms : Fxyd1 / Phospholemman / Q9Z239
  
Possible biological names infered from orthology : FXYD domain containing ion transport regulator 1 / O00168
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B1
Gene start: 31051678
Gene end: 31057199
  
Corresponding Affymetrix probe sets: 10562211 (MoGene1.0st)   1421374_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146288
Ensembl peptide - ENSMUSP00000146129
Ensembl peptide - ENSMUSP00000146295
Ensembl peptide - ENSMUSP00000048460
Ensembl peptide - ENSMUSP00000071617
Ensembl peptide - ENSMUSP00000103745
Ensembl peptide - ENSMUSP00000145589
Ensembl peptide - ENSMUSP00000145712
Ensembl peptide - ENSMUSP00000145818
Ensembl peptide - ENSMUSP00000145920
Ensembl peptide - ENSMUSP00000145990
Ensembl peptide - ENSMUSP00000146064
NCBI entrez gene - 56188     See in Manteia.
MGI - MGI:1889273
RefSeq - XM_011250652
RefSeq - NM_194321
RefSeq - XM_006540218
RefSeq - XM_006540219
RefSeq - XM_011250648
RefSeq - XM_011250649
RefSeq - XM_011250650
RefSeq - XM_011250651
RefSeq - NM_019503
RefSeq - NM_052991
RefSeq - NM_052992
RefSeq Peptide - NP_919302
RefSeq Peptide - NP_062376
RefSeq Peptide - NP_443717
RefSeq Peptide - NP_443718
swissprot - Q9Z239
swissprot - A0A0U1RPU6
swissprot - A0A0U1RPI1
Ensembl - ENSMUSG00000036570
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fxyd6lENSDARG00000097057Danio rerio
 FXYD1ENSG00000266964Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fxyd6 / Q9D164 / FXYD domain-containing ion transport regulator 6 / Q9H0Q3*ENSMUSG0000006670539
Fxyd2 / Q04646 / FXYD domain-containing ion transport regulator 2 / P54710*ENSMUSG0000005941227


Protein motifs (from Interpro)
Interpro ID Name
 IPR000272  Ion-transport regulator, FXYD motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0010734 negative regulation of protein glutathionylation ISS
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0086036 regulation of cardiac muscle cell membrane potential IMP
 biological_processGO:1903278 positive regulation of sodium ion export across plasma membrane IMP
 biological_processGO:2000649 regulation of sodium ion transmembrane transporter activity IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005890 sodium:potassium-exchanging ATPase complex ISS
 cellular_componentGO:0005901 caveola ISS
 cellular_componentGO:0014704 intercalated disc ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane ISS
 cellular_componentGO:0030315 T-tubule ISS
 cellular_componentGO:0042383 sarcolemma IMP
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0017080 sodium channel regulator activity IMP
 molecular_functionGO:0044325 ion channel binding ISS


Pathways (from Reactome)
Pathway description
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitW-v/KitW-v
Genetic Background: involves: CBA/Ca

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: KitW-v/KitW-v
Genetic Background: involves: CBA/Ca

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: KitW-v/KitW-v
Genetic Background: involves: CBA/Ca

 MP:0005599 increased cardiac muscle contractility "greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: KitW-v/KitW-v
Genetic Background: involves: CBA/Ca

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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