ENSMUSG00000036617


Mus musculus

Features
Gene ID: ENSMUSG00000036617
  
Biological name :Etl4
  
Synonyms : A2AQ25 / Etl4 / Sickle tail protein
  
Possible biological names infered from orthology : KIAA1217 / Q5T5P2
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A3
Gene start: 19909780
Gene end: 20810713
  
Corresponding Affymetrix probe sets: 10469581 (MoGene1.0st)   1426880_at (Mouse Genome 430 2.0 Array)   1432266_at (Mouse Genome 430 2.0 Array)   1432900_at (Mouse Genome 430 2.0 Array)   1432901_at (Mouse Genome 430 2.0 Array)   1440064_at (Mouse Genome 430 2.0 Array)   1457147_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110257
Ensembl peptide - ENSMUSP00000110255
Ensembl peptide - ENSMUSP00000110261
Ensembl peptide - ENSMUSP00000119778
Ensembl peptide - ENSMUSP00000116637
Ensembl peptide - ENSMUSP00000110274
Ensembl peptide - ENSMUSP00000041431
Ensembl peptide - ENSMUSP00000066170
Ensembl peptide - ENSMUSP00000110251
Ensembl peptide - ENSMUSP00000110253
Ensembl peptide - ENSMUSP00000110254
NCBI entrez gene - 208618     See in Manteia.
MGI - MGI:95454
RefSeq - XM_017316833
RefSeq - XM_006497420
RefSeq - XM_006497422
RefSeq - XM_006497423
RefSeq - XM_006497424
RefSeq - XM_006497426
RefSeq - XM_006497427
RefSeq - XM_006497428
RefSeq - XM_006497430
RefSeq - XM_011238967
RefSeq - XM_017316831
RefSeq - XM_017316832
RefSeq - NM_001081006
RefSeq - NM_001177630
RefSeq - NM_001177631
RefSeq - NM_029895
RefSeq - NM_178059
RefSeq - XM_006497408
RefSeq - XM_006497410
RefSeq - XM_006497414
RefSeq - XM_006497415
RefSeq - XM_006497417
RefSeq - XM_006497419
RefSeq Peptide - NP_001171101
RefSeq Peptide - NP_001171102
RefSeq Peptide - NP_084171
RefSeq Peptide - NP_835160
RefSeq Peptide - NP_001074475
swissprot - A2AQ25
swissprot - E9QAU4
swissprot - D3Z781
swissprot - B1AY50
swissprot - B1AY49
swissprot - Q8BHR1
Ensembl - ENSMUSG00000036617
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-207d6.2ENSDARG00000031658Danio rerio
 si:ch211-285f17.1ENSDARG00000059333Danio rerio
 KIAA1217ENSGALG00000007766Gallus gallus
 Q5T5P2ENSG00000120549Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Srcin1 / SRC kinase signaling inhibitor 1 / Q9C0H9*ENSMUSG0000003845321


Protein motifs (from Interpro)
Interpro ID Name
 IPR022782  Actin interacting protein 3-like, C-terminal
 IPR026725  Sickle tail protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0048706 embryonic skeletal system development IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000141 abnormal vertebral body morphology "malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Etl4Gt(6LSN)6029Gos/Etl4+,Etn2Sd/Etn2+
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * NMRI

Allelic Composition: Etl4Gt(pU8)80211Imeg/Etl4Gt(pU8)80211Imeg
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0000516 abnormal urinary system morphology "structural or developmental anomaly of any of the organs involved in the production or excretion of urine " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Etl4Gt(6LSN)6029Gos/Etl4+,Etn2Sd/Etn2+
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * NMRI

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Etl4Gt(6LSN)6029Gos/Etl4Gt(6LSN)6029Gos
Genetic Background: involves: 129/Sv * 129S2/SvPas

Allelic Composition: Etl4Gt(pU8)80211Imeg/Etl4Gt(pU8)80211Imeg
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
Show

Allelic Composition: Ryr2tm1.1Msnr/Ryr2+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Etl4Gt(pU8)80211Imeg/Etl4Gt(pU8)80211Imeg,Etn2Sd/Etn2+
Genetic Background: involves: C57BL/6 * CBA * Danforths duplication stock * STOCK Mcoln3Va

Allelic Composition: Etl4Gt(6LSN)6029Gos/Etl4+,Etn2Sd/Etn2+
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * NMRI

Allelic Composition: Etl4Gt(6LSN)6029Gos/Etl4Gt(6LSN)6029Gos,Etn2Sd/Etn2+
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * NMRI

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Etl4Gt(6LSN)6029Gos/Etl4Gt(6LSN)6029Gos,Etn2Sd/Etn2+
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * NMRI

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ryr2tm1.1Msnr/Ryr2+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Etl4Gt(pU8)80211Imeg/Etl4Gt(pU8)80211Imeg,Etn2Sd/Etn2+
Genetic Background: involves: C57BL/6 * CBA * Danforths duplication stock * STOCK Mcoln3Va

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ryr2tm1.1Msnr/Ryr2+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Etl4Gt(6LSN)6029Gos/Etl4Gt(6LSN)6029Gos
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0002759 abnormal caudal vertebrae morphology "malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]
Show

Allelic Composition: Etl4Gt(6LSN)6029Gos/Etl4Gt(6LSN)6029Gos
Genetic Background: involves: 129/Sv * 129S2/SvPas

Allelic Composition: Etl4Gt(pU8)80211Imeg/Etl4Gt(pU8)80211Imeg
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ryr2tm1.1Msnr/Ryr2+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Etl4Gt(6LSN)6029Gos/Etl4Gt(6LSN)6029Gos
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6

 MP:0003049 abnormal lumbar vertebrae morphology "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Etl4Gt(6LSN)6029Gos/Etl4+,Etn2Sd/Etn2+
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * NMRI

 MP:0003050 abnormal sacral vertebrae morphology "malformation of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Etl4Gt(6LSN)6029Gos/Etl4+,Etn2Sd/Etn2+
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * NMRI

 MP:0003129 persistent cloaca "the presence of a single external opening to which the urinary, digestive and reproductive tracts all connect" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91491]
Show

Allelic Composition: Etl4Gt(6LSN)6029Gos/Etl4Gt(6LSN)6029Gos,Etn2Sd/Etn2+
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * NMRI

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Etl4Gt(6LSN)6029Gos/Etl4Gt(6LSN)6029Gos,Etn2Sd/Etn2+
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * NMRI

 MP:0004173 abnormal intervertebral disk morphology "malformation of the cartilagenous and gelatinous structure found between vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Etl4Gt(pU8)80211Imeg/Etl4Gt(pU8)80211Imeg
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0004659 abnormal odontoid process "any structural anomaly of the large protuberance that projects upward from the cervical axis, around which the cervical atlas rotates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A02.835.232.834.151.383.668]
Show

Allelic Composition: Etl4Gt(6LSN)6029Gos/Etl4+,Etn2Sd/Etn2+
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * NMRI

 MP:0004683 absent intervertebral disk "absence of the cartilaginous and gelatinous structure found between vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etl4Gt(pU8)80211Imeg/Etl4Gt(pU8)80211Imeg
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etl4Gt(6LSN)6029Gos/Etl4+,Etn2Sd/Etn2+
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * NMRI

Allelic Composition: Etl4Gt(6LSN)6029Gos/Etl4Gt(6LSN)6029Gos,Etn2Sd/Etn2+
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * NMRI

 MP:0004704 short vertebral column "decreased rostral-caudal length of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ryr2tm1.1Msnr/Ryr2+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Etl4Gt(pU8)80211Imeg/Etl4Gt(pU8)80211Imeg,Etn2Sd/Etn2+
Genetic Background: involves: C57BL/6 * CBA * Danforths duplication stock * STOCK Mcoln3Va

Allelic Composition: Etl4Gt(6LSN)6029Gos/Etl4Gt(6LSN)6029Gos,Etn2Sd/Etn2+
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * NMRI

 MP:0004710 small notochord "reduced size of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ryr2tm1.1Msnr/Ryr2+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005229 abnormal intervertebral disk development "anomalous fromation of the cartilagenous and gelatinous structure found between vertebrae" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ryr2tm1.1Msnr/Ryr2+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Etl4Gt(pU8)80211Imeg/Etl4Gt(pU8)80211Imeg
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0006392 abnormal nucleus pulposus morphology "any anomaly in the structure or formation of the jelly-like substance in the middle of the spinal disc which is a remnant of the notochord" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ryr2tm1.1Msnr/Ryr2+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Etl4Gt(pU8)80211Imeg/Etl4Gt(pU8)80211Imeg
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Etl4tm1(cre)Kymm/Etl4+,Tg(CAG-EGFP-CAT-DTA)2Masa/0
Genetic Background: involves: C3H * C57BL/6NCrlj * CBA/JNCrlj

 MP:0006393 absent nucleus pulposus "missing the notochord remnant normally found in the center of the intervetebral disc" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ryr2tm1.1Msnr/Ryr2+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0010770 preweaning lethality "death anytime between fertilization and weaning (Mus: approximately 3-4 weeks of age)" [MGI:Sanger_Karp "Submission from Natasha Karp"]
Show

Allelic Composition: Etl4tm1(cre)Kymm/Etl4+,Tg(CAG-EGFP-CAT-DTA)2Masa/0
Genetic Background: involves: C3H * C57BL/6NCrlj * CBA/JNCrlj

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Etl4Gt(6LSN)6029Gos/Etl4Gt(6LSN)6029Gos,Etn2Sd/Etn2+
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * NMRI

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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