ENSMUSG00000036686


Mus musculus

Features
Gene ID: ENSMUSG00000036686
  
Biological name :Cc2d1a
  
Synonyms : Cc2d1a / Coiled-coil and C2 domain-containing protein 1A / Q8K1A6
  
Possible biological names infered from orthology : coiled-coil and C2 domain containing 1A / Q6P1N0
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C2
Gene start: 84132828
Gene end: 84147936
  
Corresponding Affymetrix probe sets: 10580100 (MoGene1.0st)   1426422_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112556
Ensembl peptide - ENSMUSP00000046449
NCBI entrez gene - 212139     See in Manteia.
MGI - MGI:2384831
RefSeq - NM_145970
RefSeq - XM_006530810
RefSeq Peptide - NP_666082
swissprot - E9PX94
swissprot - Q8K1A6
Ensembl - ENSMUSG00000036686
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO704915.1ENSDARG00000036281Danio rerio
 CC2D1AENSG00000132024Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cc2d1b / Q8BRN9 / Coiled-coil and C2 domain-containing protein 1B / Q5T0F9* / coiled-coil and C2 domain containing 1B*ENSMUSG0000002858238


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR006608  Domain of unknown function DM14
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Rgs11tm1Lex/Rgs11tm1Lex,Rgs7tm1Cjch/Rgs7tm1Cjch
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: Rgs11tm1Lex/Rgs11tm1Lex,Rgs7tm1Cjch/Rgs7tm1Cjch
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Rgs11tm1Lex/Rgs11tm1Lex,Rgs7tm1Cjch/Rgs7tm1Cjch
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

 MP:0004770 abnormal synaptic vesicle recycling "any functional anomaly in the process of the fusion of a subpopulation of synaptic vesicles with the cell membrane at the active zone, the subsequent endocytosis back from the plasma membrane, the refilling of these vesicles with neurotransmitters, and trafficking back to the active zone pool of vesicles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Rgs11tm1Lex/Rgs11tm1Lex,Rgs7tm1Cjch/Rgs7tm1Cjch
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rgs11tm1Lex/Rgs11tm1Lex,Rgs7tm1Cjch/Rgs7tm1Cjch
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004998 decreased CNS synapse formation "a reduction in the frequency of the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rgs11tm1Lex/Rgs11tm1Lex,Rgs7tm1Cjch/Rgs7tm1Cjch
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rgs11tm1Lex/Rgs11tm1Lex,Rgs7tm1Cjch/Rgs7tm1Cjch
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008406 increased cellular sensitivity to hydrogen peroxide "greater incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rgs11tm1Lex/Rgs11tm1Lex,Rgs7tm1Cjch/Rgs7tm1Cjch
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
Show

Allelic Composition: Shhtm3(cre)Chg/Shhtm3(cre)Chg
Genetic Background: Not Specified

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Shhtm3(cre)Chg/Shhtm3(cre)Chg
Genetic Background: Not Specified

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Rgs11tm1Lex/Rgs11tm1Lex,Rgs7tm1Cjch/Rgs7tm1Cjch
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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