ENSMUSG00000036822


Mus musculus

Features
Gene ID: ENSMUSG00000036822
  
Biological name :Topors
  
Synonyms : E3 ubiquitin-protein ligase Topors / Q80Z37 / Topors
  
Possible biological names infered from orthology : Q9NS56 / TOP1 binding arginine/serine rich protein
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A5
Gene start: 40259601
Gene end: 40269850
  
Corresponding Affymetrix probe sets: 10512088 (MoGene1.0st)   1417754_at (Mouse Genome 430 2.0 Array)   1417755_at (Mouse Genome 430 2.0 Array)   1448838_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046843
NCBI entrez gene - 106021     See in Manteia.
MGI - MGI:2146189
RefSeq - NM_134097
RefSeq Peptide - NP_598858
swissprot - Q80Z37
Ensembl - ENSMUSG00000036822
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 toporsaENSDARG00000037260Danio rerio
 TOPORSENSGALG00000020523Gallus gallus
 Q9NS56ENSG00000197579Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Toporsl / topoisomerase I binding, arginine/serine-rich likeENSMUSG0000002831414


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006513 protein monoubiquitination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0016925 protein sumoylation IEA
 biological_processGO:0034504 protein localization to nucleus IEA
 biological_processGO:0042127 regulation of cell proliferation IDA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IGI
 biological_processGO:0051443 positive regulation of ubiquitin-protein transferase activity IEA
 biological_processGO:0051457 maintenance of protein location in nucleus IEA
 biological_processGO:0070936 protein K48-linked ubiquitination IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0000930 gamma-tubulin complex IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0016605 PML body ISS
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0032391 photoreceptor connecting cilium IDA
 cellular_componentGO:0036064 ciliary basal body IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003823 antigen binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019789 SUMO transferase activity IEA
 molecular_functionGO:0044547 DNA topoisomerase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of immune response proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex






 

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