ENSMUSG00000036918


Mus musculus

Features
Gene ID: ENSMUSG00000036918
  
Biological name :Ttc7
  
Synonyms : Q8BGB2 / tetratricopeptide repeat domain 7 / Ttc7
  
Possible biological names infered from orthology : Q9ULT0 / tetratricopeptide repeat domain 7A / TTC7A
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E4
Gene start: 87282886
Gene end: 87381769
  
Corresponding Affymetrix probe sets: 10447361 (MoGene1.0st)   1429740_at (Mouse Genome 430 2.0 Array)   1435334_at (Mouse Genome 430 2.0 Array)   1446522_at (Mouse Genome 430 2.0 Array)   1459329_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122563
Ensembl peptide - ENSMUSP00000040771
Ensembl peptide - ENSMUSP00000114181
Ensembl peptide - ENSMUSP00000115351
NCBI entrez gene - 225049     See in Manteia.
MGI - MGI:1920999
RefSeq - XM_017317451
RefSeq - NM_028639
RefSeq - XM_006524201
RefSeq - XM_006524202
RefSeq Peptide - NP_082915
swissprot - Q8BGB2
swissprot - F6ZVR4
swissprot - D6RG81
swissprot - D3Z0R8
Ensembl - ENSMUSG00000036918
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ttc7aENSDARG00000074760Danio rerio
 TTC7AENSGALG00000010020Gallus gallus
 TTC7AENSG00000068724Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ttc7b / E9Q6P5 / tetratricopeptide repeat domain 7B / Q86TV6*ENSMUSG0000003353049


Protein motifs (from Interpro)
Interpro ID Name
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR026900  Tetratricopeptide repeat protein 7A


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006879 cellular iron ion homeostasis IMP
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0072659 protein localization to plasma membrane IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000192 abnormal mineral level "anomalous concentration of any inorganic substance that has importance in body functions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ercc1tm2Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ercc1tm2Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0000471 abnormal stomach epithelium morphology "malformation of the epithelial layer of the stomach " [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: A/J

 MP:0000472 abnormal stomach squamous epithelium morphology "malformation of the scaly epithelial layer of the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: A/J

 MP:0000579 abnormal nail morphology "structural or developmental anomaly of any of the thin, horny, translucent plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0000580 deformed nails "atypical shape or size of the nails" [J:45400]
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: involves: A/J * BALB/cByJ

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: CBy.INT-Ttc7fsn-Jic

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: CBy.INT-Ttc7fsn-Jic

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ercc1tm2Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ercc1tm2Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

 MP:0000711 thymic cortex hypoplasia "reduced cell number in the outer portion of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: B6.INT-Ttc7fsn-Jic

Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
Show

Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: CBy.INT-Ttc7fsn-Jic

 MP:0001195 flaky skin "shedding scales on the skin " [J:56641]
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: involves: A/J * BALB/cByJ

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: involves: A/J * BALB/cByJ

 MP:0001220 epidermal necrosis "pathological cell death in the epidermal layer of the skin, usually due to irreversible damage" [J:65146]
Show

Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001246 mixed cellular infiltration to dermis "gradual accumulation of mixed cell types in the dermis that are not normally found there" [J:65416]
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ercc1tm2Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Ercc1tm2Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: A/J

Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: B6.INT-Ttc7fsn-Jic

Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: CBy.INT-Ttc7fsn-Jic

Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0001586 abnormal erythrocyte count "altered number of red blood cells per volume in the bloodstream" [J:53370]
Show

Allelic Composition: Ercc1tm2Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

 MP:0001770 abnormal iron level "anomalous concentrations of this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: A/J

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0002014 papilloma "benign epithelial tumor" [J:47225]
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: A/J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ercc1tm2Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stx2repro34/Stx2repro34
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Ttc7fsn/Ttc7fsn-Jic
Genetic Background: involves: A/J * BALB/c * C57BL/6 * INT

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ercc1tm2Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ercc1tm2Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ercc1tm2Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

 MP:0002594 low mean erythrocyte count "less than average numbers of red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ercc1tm2Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Ercc1tm2Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Ercc1tm2Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

 MP:0002643 poikilocytosis "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Ercc1tm2Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: involves: A/J * BALB/cByJ

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ercc1tm2Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

 MP:0003427 parakeratosis "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: B6.INT-Ttc7fsn-Jic

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: involves: A/J * BALB/cByJ

 MP:0003810 abnormal hair cuticle "anomalies in the thin, smooth and glossy outer protective cell layer of hair shaft" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: involves: A/J * BALB/cByJ

 MP:0004152 abnormal circulating iron level "anomalous blood concentration of this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0005096 erythroblastosis "presence of erythroblasts in great number in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
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Allelic Composition: Ercc1tm2Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

 MP:0005097 polychromatophilia "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
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Allelic Composition: Ercc1tm2Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

 MP:0005174 abnormal tail pigmentation "anomalous color of the tail in relation to control animals" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: B6.INT-Ttc7fsn-Jic

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0008255 decreased megakaryocyte cell number "reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Ercc1tm2Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0008479 decreased spleen white pulp amount "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0009600 hypergranulosis "increased thickness of the granular layer of the epidermis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: involves: A/J * BALB/cByJ

 MP:0009602 abnormal keratohyalin granule morphology "any structural anomaly of the irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis that may play a role in keratinization and barrier function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: involves: A/J * BALB/cByJ

 MP:0009675 orthokeratosis "thickening of the stratum corneum of the epidermis (hyperkeratosis) with non-nucleated keratinocytes retained in this layer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

 MP:0010176 dacryocytosis "presence of teardrop-shaped red blood cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0010177 acanthocytosis "presence of erythrocytes characterized by multiple spiny (thorn-like) cytoplasmic projections" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0010784 abnormal forestomach morphology "any structural anomaly of the dilated area of tissue where the stomach and esophagus meet" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: A/J

 MP:0010792 abnormal stomach mucosa morphology "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: A/J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ercc1tm2Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: B6.INT-Ttc7fsn-Jic

Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: CBy.INT-Ttc7fsn-Jic

Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: C3.INT-Ttc7fsn-Jic

 MP:0011242 increased fetal derived definitive erythrocyte cell number "increased number of fetal liver derived enucleated erythrocytes, which mature in macrophage islands within the liver, enucleate, and then enter the bloodstream; these resemble adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemoglobins" [CL:0002357, PMID:18282515]
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Allelic Composition: Ttc7fsn-Jic/Ttc7fsn-Jic
Genetic Background: B6.INT-Ttc7fsn-Jic

 MP:0011413 colorless urine "absence of the usual straw-coloration of the urine" [MGI:anna]
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Allelic Composition: Ercc1tm2Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0013409 increased dendritic epidermal T cell number 
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: involves: A/J * BALB/cByJ

 MP:0013412 increased Langerhans cell number "increase in the number of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [IMPC:Saran, ISBN:0781735149]
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: involves: A/J * BALB/cByJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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