ENSMUSG00000036983


Mus musculus

Features
Gene ID: ENSMUSG00000036983
  
Biological name :Tfb1m
  
Synonyms : Dimethyladenosine transferase 1, mitochondrial / Q8JZM0 / Tfb1m
  
Possible biological names infered from orthology : Q8WVM0 / transcription factor B1, mitochondrial
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A1
Gene start: 3519263
Gene end: 3557713
  
Corresponding Affymetrix probe sets: 10447521 (MoGene1.0st)   1435924_at (Mouse Genome 430 2.0 Array)   1449749_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035291
NCBI entrez gene - 224481     See in Manteia.
MGI - MGI:2146851
RefSeq - NM_146074
RefSeq - XM_006523220
RefSeq Peptide - NP_666186
swissprot - Q8JZM0
Ensembl - ENSMUSG00000036983
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tfb1mENSDARG00000040727Danio rerio
 TFB1MENSGALG00000013647Gallus gallus
 TFB1MENSG00000029639Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dimt1 / Q9D0D4 / Probable dimethyladenosine transferase / Q9UNQ2* / DIM1 dimethyladenosine transferase 1 homolog*ENSMUSG0000002169223


Protein motifs (from Interpro)
Interpro ID Name
 IPR001737  Ribosomal RNA adenine methyltransferase KsgA/Erm
 IPR011530  Ribosomal RNA adenine dimethylase
 IPR020596  Ribosomal RNA adenine methylase transferase, conserved site
 IPR020598  Ribosomal RNA adenine methylase transferase, N-terminal
 IPR023165  rRNA adenine dimethylase-like
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000154 rRNA modification IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0031167 rRNA methylation IEA
 biological_processGO:0032259 methylation IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0042645 mitochondrial nucleoid IEA
 molecular_functionGO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008649 rRNA methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Nfatc1tm1Glm/Nfatc1tm1Glm
Genetic Background: involves: 129S2/SvPas

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Nfatc1tm1Glm/Nfatc1tm1Glm
Genetic Background: involves: 129S2/SvPas

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Nfatc1tm1Glm/Nfatc1tm1Glm
Genetic Background: involves: 129S2/SvPas

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfatc1tm1Glm/Nfatc1tm1Glm
Genetic Background: involves: 129S2/SvPas

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Nfatc1tm1Glm/Nfatc1tm1Glm
Genetic Background: involves: 129S2/SvPas

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfatc1tm1Glm/Nfatc1tm1Glm
Genetic Background: involves: 129S2/SvPas

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
Show

Allelic Composition: Nfatc1tm1Glm/Nfatc1tm1Glm
Genetic Background: involves: 129S2/SvPas

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Nfatc1tm1Glm/Nfatc1tm1Glm
Genetic Background: involves: 129S2/SvPas

 MP:0011388 absent heart "absence of the hollow, muscular organ that maintains the circulation of the blood" [MGI:smb]
Show

Allelic Composition: Nfatc1tm1Glm/Nfatc1tm1Glm
Genetic Background: involves: 129S2/SvPas

 MP:0011389 absent optic disc "absence of the area in the retina where all of the axons of the ganglion cells exit the retina to form the optic nerve" [MGI:smb]
Show

Allelic Composition: Nfatc1tm1Glm/Nfatc1tm1Glm
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr