ENSMUSG00000037253


Mus musculus

Features
Gene ID: ENSMUSG00000037253
  
Biological name :Mex3c
  
Synonyms : Mex3c / Q05A36 / RNA-binding E3 ubiquitin-protein ligase MEX3C
  
Possible biological names infered from orthology : mex-3 RNA binding family member C / Q5U5Q3
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E2
Gene start: 73573044
Gene end: 73592575
  
Corresponding Affymetrix probe sets: 10456579 (MoGene1.0st)   1444701_at (Mouse Genome 430 2.0 Array)   1454612_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000089463
NCBI entrez gene - 240396     See in Manteia.
MGI - MGI:2652843
RefSeq - NM_001039214
RefSeq Peptide - NP_001034303
swissprot - Q05A36
Ensembl - ENSMUSG00000037253
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MEX3CENSG00000176624Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mex3b / mex-3 RNA binding family member B / Q6ZN04*ENSMUSG0000005770645
Mex3d / mex-3 RNA binding family member D / Q86XN8*ENSMUSG0000004869640
Mex3a / mex-3 RNA binding family member A / A1L020*ENSMUSG0000007448035


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR004087  K Homology domain
 IPR004088  K Homology domain, type 1
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014721  Ribosomal protein S5 domain 2-type fold, subgroup
 IPR036612  K Homology domain, type 1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003415 chondrocyte hypertrophy IMP
 biological_processGO:0045598 regulation of fat cell differentiation IMP
 biological_processGO:0097009 energy homeostasis IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Epas1tm1Yms/Epas1tm1Yms,Tg(Vil-cre)20Syr/0
Genetic Background: B6.Cg-Epas1tm1Yms Tg(Vil-cre)20Syr

Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Camk2atm1Kub/Camk2atm1Kub
Genetic Background: involves: 129 * C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: B6.129P2-Mex3cGt(DD0642)Wtsi

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Epas1tm1Yms/Epas1tm1Yms,Tg(Vil-cre)20Syr/0
Genetic Background: B6.Cg-Epas1tm1Yms Tg(Vil-cre)20Syr

Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: B6.129P2-Mex3cGt(DD0642)Wtsi

Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Epas1tm1Yms/Epas1tm1Yms,Tg(Vil-cre)20Syr/0
Genetic Background: B6.Cg-Epas1tm1Yms Tg(Vil-cre)20Syr

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Epas1tm1Yms/Epas1tm1Yms,Tg(Vil-cre)20Syr/0
Genetic Background: B6.Cg-Epas1tm1Yms Tg(Vil-cre)20Syr

Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Camk2atm1Kub/Camk2atm1Kub
Genetic Background: involves: 129 * C57BL/6

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Epas1tm1Yms/Epas1tm1Yms,Tg(Vil-cre)20Syr/0
Genetic Background: B6.Cg-Epas1tm1Yms Tg(Vil-cre)20Syr

Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Epas1tm1Yms/Epas1tm1Yms,Tg(Vil-cre)20Syr/0
Genetic Background: B6.Cg-Epas1tm1Yms Tg(Vil-cre)20Syr

Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

 MP:0005123 increased circulating growth hormone level "greater than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Epas1tm1Yms/Epas1tm1Yms,Tg(Vil-cre)20Syr/0
Genetic Background: B6.Cg-Epas1tm1Yms Tg(Vil-cre)20Syr

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Epas1tm1Yms/Epas1tm1Yms,Tg(Vil-cre)20Syr/0
Genetic Background: B6.Cg-Epas1tm1Yms Tg(Vil-cre)20Syr

Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
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Allelic Composition: Camk2atm1Kub/Camk2atm1Kub
Genetic Background: involves: 129 * C57BL/6

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Camk2atm1Kub/Camk2atm1Kub
Genetic Background: involves: 129 * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Camk2atm1Kub/Camk2atm1Kub
Genetic Background: involves: 129 * C57BL/6

 MP:0008831 abnormal insulin-like growth factor I level "aomaly in the concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MESH:D12.644.276.937.400, MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: B6.129P2-Mex3cGt(DD0642)Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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