ENSMUSG00000057706


Mus musculus

Features
Gene ID: ENSMUSG00000057706
  
Biological name :Mex3b
  
Synonyms : Mex3b / mex-3 RNA binding family member B
  
Possible biological names infered from orthology : Q6ZN04
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: D3
Gene start: 82867333
Gene end: 82871515
  
Corresponding Affymetrix probe sets: 10554655 (MoGene1.0st)   1437152_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000082168
NCBI entrez gene - 108797     See in Manteia.
MGI - MGI:1918252
RefSeq - NM_175366
RefSeq Peptide - NP_780575
swissprot - F8WJD6
Ensembl - ENSMUSG00000057706
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mex3bENSDARG00000058369Danio rerio
 MEX3BENSGALG00000032984Gallus gallus
 MEX3BENSG00000183496Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mex3c / Q05A36 / RNA-binding E3 ubiquitin-protein ligase MEX3C / Q5U5Q3* / mex-3 RNA binding family member C*ENSMUSG0000003725351
Mex3d / mex-3 RNA binding family member D / Q86XN8*ENSMUSG0000004869649
Mex3a / mex-3 RNA binding family member A / A1L020*ENSMUSG0000007448044


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR004087  K Homology domain
 IPR004088  K Homology domain, type 1
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR036612  K Homology domain, type 1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Mex3btm1.1Mbld/Mex3btm1.1Mbld,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

Allelic Composition: Mex3btm1.1Mbld/Mex3btm1.1Mbld,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0002776 Sertoli cell hyperplasia "increased number of cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:71710, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

Allelic Composition: Mex3btm1.1Mbld/Mex3btm1.1Mbld,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008868 abnormal granulosa cell morphology "any structural anomaly of a supporting cell for the developing female gamete in the ovary of mammals; granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle" [MESH:A.05.360.319.114.630.535.200]
Show

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0009853 decreased Sertoli cell phagocytosis "decreased phagocytic activity of testicular Sertoli cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
Show

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0020142 increased anti-sperm antibody level "elevated level of antibodies to sperm antigens, usually due to compromised Sertoli cell barrier (blood-testis barrier) function; ASAs may be found in the circulation, either free or as immune complexes, in seminal fluid and/or attached to various antigenic sites on the sperm surface (head, midpiece or tail)" [PMID:24803656]
Show

Allelic Composition: Mex3btm1.1Mbld/Mex3btm1.1Mbld,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0020355 abnormal Sertoli cell barrier morphology "any structural anomaly of the physical barrier found between adjacent Sertoli cells within the seminiferous tubules; the sertoli cell barrier consists of several types of cellular junctions including tight junctions, gap junctions and adhesion junctions, and divides the seminiferous tubules into the basal and apical (adluminal) compartments" [PMID:24713828 http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=4;spage=572;epage=580;aulast=Jiang]
Show

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0020356 abnormal Sertoli cell barrier function "any functional anomaly of the physical barrier found between the blood vessels and the seminiferous tubules of the testes; this barrier between Sertoli cells is composed of tight junctions, basal ectoplasmic specializations, and desmosome-like junctions" [https://en.wikipedia.org/wiki/Blood%E2%80%93testis_barrier, PMID:24713828 http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=4;spage=572;epage=580;aulast=Jiang, PMID:24803656]
Show

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

Allelic Composition: Mex3btm1.1Mbld/Mex3btm1.1Mbld,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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