| MP:0000260 | abnormal angiogenesis | "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ovol2tm1Sito/Ovol2tm1Sito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0000267 | abnormal cardiac development | "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Ovol2tm1Sito/Ovol2tm1Sito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0000269 | abnormal looping morphogenesis | "atypical bending of the primitive heart tube during early development" [J:27443] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Ovol2tm1Sito/Ovol2tm1Sito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0000270 | abnormal heart tube morphology | "malformed embryonic heart " [J:37888] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0000293 | absent myocardial trabeculae | "absence of the supporting bundles of muscular fibers lining the walls of the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ovol2tm1Sito/Ovol2tm1Sito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0000474 | abnormal foregut morphology | "malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0000928 | incomplete cephalic closure | "arrest of the fusion of the cephalic neural folds" [J:12622] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0000929 | open neural tube | "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571] |
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Allelic Composition: Ovol2tm1Sito/Ovol2tm1Sito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0001622 | abnormal vasculogenesis | "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ovol2tm1Sito/Ovol2tm1Sito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
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Allelic Composition: Ovol2tm1Sito/Ovol2tm1Sito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0001700 | abnormal embryo turning | "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0001704 | abnormal dorsal-ventral axis patterning | "anomaly in the development or formation of the axis that runs from the front to the back surface of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0001719 | absent vitelline blood vessels | "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623] |
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Allelic Composition: Ovol2tm1Sito/Ovol2tm1Sito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ovol2tm1Sito/Ovol2tm1Sito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0002085 | abnormal embryonic tissue morphology | "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: H2b/H2b,Nfkbidtm1Clay/Nfkbidtm1Clay,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraN15,TcrbN15)L2Elre/?
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6
|
| MP:0002086 | abnormal extraembryonic tissue morphology | "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: H2b/H2b,Nfkbidtm1Clay/Nfkbidtm1Clay,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraN15,TcrbN15)L2Elre/?
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6
|
| MP:0002128 | abnormal blood circulation | "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: H2b/H2b,Nfkbidtm1Clay/Nfkbidtm1Clay,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraN15,TcrbN15)L2Elre/?
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6
|
| MP:0002188 | small heart | "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044] |
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Allelic Composition: Ovol2tm1Sito/Ovol2tm1Sito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0002825 | abnormal notochord | "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0003054 | spina bifida | "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0003119 | abnormal digestive system development | "dysmorphology of the organ system that converts ingested food to nutrients and energy" [smb:Susan M. Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0003229 | abnormal vitelline vasculature | "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257] |
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Allelic Composition: Ovol2tm1Sito/Ovol2tm1Sito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0003231 | abnormal placental vasculature | "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157] |
Show
Allelic Composition: Ovol2tm1Sito/Ovol2tm1Sito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0003232 | abnormal forebrain development | "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0003874 | absent branchial arches | "missing the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Ovol2tm1Sito/Ovol2tm1Sito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0003974 | abnormal endocardium morphology | "malformation of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ovol2tm1Sito/Ovol2tm1Sito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ovol2tm1Sito/Ovol2tm1Sito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0004076 | abnormal vitelline vascular remodelling | "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ovol2tm1Sito/Ovol2tm1Sito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0004187 | cardia bifida | "failure of the bilateral myocardial cells to coalesce into a single central heart tube resulting in the presence of two independent hearts" [smb:Susan M Bello, Mouse Genome Informatics Curator ""] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0004261 | abnormal embryonic neuroepithelium morphology | "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0004387 | abnormal prechordal plate morphology | "any structural anomaly of the horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann s organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0005294 | abnormal heart ventricle morphology | "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ovol2tm1Sito/Ovol2tm1Sito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0006305 | abnormal optic eminence morphology | "malformation of the embryonic structure that gives rise to the corneal ectoderm" [J:119812, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", UNSW_embryology site:http://embryology.med.unsw.edu.au/Notes/eye.htm#stage13] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0006346 | small branchial arch | "reduced size of one or more of the branchial arches" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0008786 | abnormal hindgut morphology | "any structural anomaly of the caudal portion of the primitive digestive tube of the embryo" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0008803 | abnormal placental labyrinth vasculature morphology | "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ovol2tm1Sito/Ovol2tm1Sito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0010432 | common ventricle | "the presence of only one working lower chamber in the heart, usually with a virtual absence of the ventricular septum and usually present in conjunction with double inlet left or right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Ovol2tm1Sito/Ovol2tm1Sito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0011259 | abnormal cephalic neural fold morphology | "any structural anomaly of the elevated margins of the neural groove that are located in the future cephalic region of the embryo" [ISBN:0-683-40008-8, MGI:csmith] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0011260 | abnormal head mesenchyme morphology | "any structural anomaly of the primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells" [ISBN:0-683-40008-8] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0012155 | abnormal optic pit morphology | "any structural anomaly of the depression found on each side of the end of the neural ectoderm (or neural tube) of the embryo; the pit deepens to form the optic vesicle" [MGI:anna] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0012254 | absent intersomitic vessels | "absence of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna] |
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Allelic Composition: Ovol2tm1Sito/Ovol2tm1Sito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0012510 | abnormal aortic sac morphology | "any structural abnormality of the dilated structure that is lined by endothelial cells and located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates" [MGI:anna] |
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Allelic Composition: Ovol2tm1Sito/Ovol2tm1Sito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0012532 | abnorrmal surface ectoderm morphology | "any structural anomaly of the surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm; cells from the surface ectoderm differentiate to form the epidermis; epithelia lining the mouth and nasal cavities; hair follicles and nails; the lacrimal, tarsal, salivary, sebaceous, sweat, and mammary glands, and anterior pituitary gland (adenohypophysis); inner and outer ear structures; the lens, and conjunctival and corneal epithelia; dental enamel; and the apical ectodermal ridge inducing development of the limb buds" [MGI:anna, UBERON:0000076] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0012702 | increased embryonic neuroepithelium thickness | "increased width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0012706 | decreased embryonic neuroepithelial cell proliferation | "decrease in the expansion rate of the cells of the embryonic neuroepithelium by cell division" [CL:0000710, MGI:anna] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0012744 | increased neural crest cell apoptosis | "increased number of (any population) of neural crest cells undergoing programmed cell death" [MGI:anna] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0012746 | abnormal neural crest cell delamination | "any anomaly in the process by which a neural crest cell (NCC) physically dissociates from the neuroepithelium in the dorsal aspect of the neural tube; premigratory NCCs exist within a fully polarized epithelial layer, adjoined by adherens junctions and tight junctions; NCC delamination involves an epithelial-mesenchymal transition (EMT) during which epithelial cells are converted into migratory mesenchymal cells; EMT requires loss of apical-basal cell polarity and dissolution of tight junctions and is accompanied by changes in cytoskeletal organization and a switch in adhesive properties so that cells can separate from the neuroepithelium and emigrate" [MGI:anna] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0030061 | absent otic pit | "absence of the paired depression of thickened otic placode epithelium marking the location of the future otic vesicles" [MGI:anna] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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