ENSMUSG00000024922


Mus musculus

Features
Gene ID: ENSMUSG00000024922
  
Biological name :Ovol1
  
Synonyms : Ovol1 / Putative transcription factor Ovo-like 1 / Q9WTJ2
  
Possible biological names infered from orthology : O14753 / ovo like transcriptional repressor 1
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 5549137
Gene end: 5560575
  
Corresponding Affymetrix probe sets: 10465106 (MoGene1.0st)   1419051_at (Mouse Genome 430 2.0 Array)   1419052_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025861
NCBI entrez gene - 18426     See in Manteia.
MGI - MGI:1330290
RefSeq - XM_011248606
RefSeq - NM_019935
RefSeq - XM_006531675
RefSeq - XM_006531676
RefSeq Peptide - NP_064319
swissprot - Q9WTJ2
Ensembl - ENSMUSG00000024922
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ovol1aENSDARG00000076472Danio rerio
 ovol1bENSDARG00000078256Danio rerio
 OVOL1ENSG00000172818Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ovol2 / Q8CIV7 / Transcription factor Ovo-like 2 / Q9BRP0* / ovo like zinc finger 2*ENSMUSG0000003727954
Ovol3 / D3YYM0 / Putative transcription factor ovo-like protein 3 / O00110* / ovo like zinc finger 3*ENSMUSG0000010051235
Q8BXX2 / Zbtb49 / zinc finger and BTB domain containing 49 / Q6ZSB9*ENSMUSG0000002912724
Mynn / Q99MD8 / Myoneurin / Q9NPC7*ENSMUSG0000003773022


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR027756  Ovo-like
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007498 mesoderm development IMP
 biological_processGO:0008544 epidermis development IMP
 biological_processGO:0043588 skin development IMP
 biological_processGO:0051729 germline cell cycle switching, mitotic to meiotic cell cycle IMP
 biological_processGO:1901994 negative regulation of meiotic cell cycle phase transition IMP
 biological_processGO:2000647 negative regulation of stem cell proliferation IGI
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000398 splitting of guard hairs "intercellular splits and kinks within or along the hair shaft of the longest and straightest of the four hair types" [J:50844]
Show

Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000400 abnormal awl hair "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000405 abnormal auchene hairs "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000420 ruffled hair "fuzzy, irregular appearance of the hair" [J:50844]
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Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000522 cysts in kidney cortex "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]
Show

Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001123 dilated uterus "stretched or enlarged female muscular organ of gestation" [J:50844]
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Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001136 dilated cervix "stretched or enlarged lower opening of the uterus to the vagina" [J:50844]
Show

Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001143 constricted vaginal opening "shrunken, narrowed external vaginal opening" [J:50844]
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Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001144 fused vaginal opening "condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Nampttm1.1(KOMP)Vlcg/Nampttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nampttm1.1(KOMP)Vlcg/Nampttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Ly6atm1Pmf/Ly6atm1Pmf
Genetic Background: C.129P2-Ly6atm1Pmf

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ovol1tm1Efu/Ovol1tm1Efu
Genetic Background: B6.129-Ovol1tm1Efu

Allelic Composition: Ovol1tm1Efu/Ovol1+
Genetic Background: B6.129-Ovol1tm1Efu

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004970 kidney atrophy "wasting of the kidney due to injury or disease, resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ovol1tm1Efu/Ovol1tm1Efu
Genetic Background: B6.129-Ovol1tm1Efu

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ovol1tm1Efu/Ovol1tm1Efu
Genetic Background: B6.129-Ovol1tm1Efu

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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